Allergen Component Testing in the Diagnosis of Food Allergy

Schussler, Edith; Kattan, Jacob D.

doi:10.1007/s11882-015-0554-9

Cited by 11 publications

(4 citation statements)

References 54 publications

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“…Detection of allergen sensitization has conventionally been undertaken using skin prick tests (SPT) and/or immunoassays of serum‐specific IgE (sIgE) levels, but these approaches are hampered by the fact that cross‐reactive molecules, such as serum albumin, are present in the extracts used, which can lead to an overestimation of sensitization rates to a particular allergen . Over the last decade, the use of molecular‐based component‐resolved diagnostics has increased, offering the opportunity to characterize individual allergenic molecules, specific phenotypes of allergens, as well as a possibility of detecting potential cross‐reactivity to allergens . While increasing number of studies have described the patterns of allergen components in childhood populations, only very few component‐resolved studies have been conducted in adult populations.…”

Section: Introductionmentioning

confidence: 99%

Characterization of sensitization to furry animal allergen components in an adult population

Suzuki

Nwaru

Ekerljung

et al. 2019

Clin Experimental Allergy

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Background: There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.Objective: To characterize sensitization patterns to furry animal allergen components in Swedish adults.Methods: Based on the West Sweden Asthma Study, a random population (n = 1103) and an asthma sample (n = 769) were tested for allergen sensitization using Phadiatop ® .Those with IgE ≥ 0.35 kU A /L were tested for cat (Fel d 1, 2, and 4), dog (Can f 1, 2, 3, and 5), and horse (Equ c 1) allergen component sensitization. We defined allergen component poly-sensitization patterns, identified data-driven sensitization clusters, described component sensitization overlaps, and assessed determinants of sensitization patterns.

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Section: Introductionmentioning

confidence: 99%

Characterization of sensitization to furry animal allergen components in an adult population

Suzuki

Nwaru

Ekerljung

et al. 2019

Clin Experimental Allergy

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“…However, the DBPCFC test is costly and time consuming for the patients, which warrants the search for cheaper and simpler alternatives. The performance of in vitro diagnosis of food allergy has recently improved with the use of component‐resolved diagnosis (CRD) . CRD measures sIgE against individual allergens utilizing purified or recombinant allergens.…”

Section: Introductionmentioning

confidence: 99%

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

Valk

Wijk

Vergouwe

et al. 2016

Clin Experimental Allergy

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SummaryBackground The double-blind, placebo-controlled food challenge test (DBPCFC) is the gold standard in cashew nut allergy. This test is costly, time consuming and not without side effects. Analysis of IgE reactivity to cashew nut components may reduce the need for food challenge tests. Methods In a prospective and multicentre study, children with suspected cashew nut allergy underwent a DBPCFC with cashew nut. Specific IgE to cashew nut and to the components Ana o 1, 2 and 3 were determined. A skin prick test (SPT) with cashew nut extract was performed.The association between the outcome of the food challenge test and specific IgE to Ana o 1, 2 and 3 was assessed with logistic regression analyses, unadjusted and adjusted for other diagnostic variables. Discriminative ability was quantified with a concordance index (c). Results A total of 173 children (103 boys, 60%) with a median age of 9 years were included. About 79% had a positive challenge test outcome. A steep rise in the risk of a positive challenge was observed for specific IgE to each individual component Ana o 1, 2 and 3 with estimated risks up to approximately 100%. Median values of Ana o 1, 2, 3 were 1.29 kU/l (range 0-100 kU/l), 4.77 kU/l (range 0-100 kU/l) and 8.33 kU/l (range 0-100 kU/l) respectively and varied significantly (p < 0.001). Specific IgE to Ana o 1, 2 and 3 was better distinguished between cashew-allergic and tolerant children (c = 0.87, 0.85 and 0.89, respectively) than specific IgE to cashew nut or SPT (c = 0.76 and 0.83, respectively). Conclusion The major cashew nut allergens Ana o 1, 2 and 3 are each individually predictive for the outcome of food challenge tests in cashew-allergic children.

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“…We are aware that lack of component-resolved diagnostics may be a limitation of our study, but it is important to note that oral food challenge and the correlation of clinical symptoms with ingested foods still have a decisive role in diagnosis of food allergy [ 2 , 11 ]. It is also worth noticing that all allergic tests can be positive to foods even if they are well tolerated and the benefits are still questionable for a number of major allergens [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Pollen-related food allergy in children with seasonal allergic rhinitis

Cudowska¹,

Pawłowicz²,

Lebensztejn³

2021

pdia

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Introduction Seasonal allergic rhinitis (SAR) and bronchial asthma are typical manifestations of pollen-food sensitization in adults. There is limited information regarding the sensitization patterns of pollen-food allergy in children. Aim To evaluate the prevalence of SAR in children with pollen-food sensitization and assess the impact of food allergens on nasal symptoms. Material and methods Forty-three children with pollen-food sensitization aged 2–14 years were evaluated for evidence of SAR. The inclusion criteria was IgE-mediated sensitization to pollen and homologous food allergens. The control group consisted of 19 children with SAR caused by pollen without sensitization to homologous food allergens. Results Allergic rhinitis was the main symptom in 65.1% of children; in 25.6% an association between ingestion of pollen-related foods and nasal symptoms was observed. The simultaneous sensitization to animal origin food allergens was stated in 63.3% of children with SAR. In 25.6% anaphylactic reactions to foods were registered. 37.2% of children were asymptomatic to pollen origin foods despite pollen-food sensitization. The statistically significant differences between values were noticed in comparison to the control group. Conclusions Allergic rhinitis is a common manifestation of pollen-food sensitization in children and this type of immunological hyperreactivity should be taken into account regardless of age. The lack of association of symptoms with plant origin foods in the majority of cases and the asymptomatic course of food sensitization in more than one third of patients indicates the need for follow-up and being careful in routine recommending the avoidance diet.

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Allergen Component Testing in the Diagnosis of Food Allergy

Cited by 11 publications

References 54 publications

Characterization of sensitization to furry animal allergen components in an adult population

Characterization of sensitization to furry animal allergen components in an adult population

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

Pollen-related food allergy in children with seasonal allergic rhinitis

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