Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs

Rahman, Mohibur; Phookan, Arundhati; Zaman, G.; Das, Arpana; Akhtar, F.; Tamuly, Shantanu; Choudhury, H.; Sarma, Lipika

doi:10.1007/s11250-021-02756-6

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…Thus, lactation is the key, and a high LS is associated with lower lactation than a low LS. Doom's pigs in the high-LS group had a lower birth weight than those in the low-LS group, and there was no significant difference in weaning weight, indicating that low-LS sows have higher lactation yields [25]. Based on our research, only two studies have reported pig lactation [1,28].…”

Section: Lactationmentioning

confidence: 71%

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Effect of SNPs on Litter Size in Swine

Guo,

Lv,

Liu

et al. 2024

CIMB

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Although sows do not directly enter the market, they play an important role in piglet breeding on farms. They consume large amounts of feed, resulting in a significant environmental burden. Pig farms can increase their income and reduce environmental pollution by increasing the litter size (LS) of swine. PCR-RFLP/SSCP and GWAS are common methods to evaluate single-nucleotide polymorphisms (SNPs) in candidate genes. We conducted a systematic meta-analysis of the effect of SNPs on pig LS. We collected and analysed data published over the past 30 years using traditional and network meta-analyses. Trial sequential analysis (TSA) was used to analyse population data. Gene set enrichment analysis and protein–protein interaction network analysis were used to analyse the GWAS dataset. The results showed that the candidate genes were positively correlated with LS, and defects in PCR-RFLP/SSCP affected the reliability of candidate gene results. However, the genotypes with high and low LSs did not have a significant advantage. Current breeding and management practices for sows should consider increasing the LS while reducing lactation length and minimizing the sows’ non-pregnancy period as much as possible.

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Section: Lactationmentioning

confidence: 71%

“…Doom's pig research showed that with a high LS, the total weight of piglets (litter weight) is low [25]. The study shows that Indian indigenous pigs with a high LS have a higher litter weight than low-LS pigs.…”

Section: Relationship Between Ls and Litter Weightmentioning

confidence: 83%

Effect of SNPs on Litter Size in Swine

Guo,

Lv,

Liu

et al. 2024

CIMB

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“…In order to analysis roles of DE miRNAs, RNA-seq were used to identify the potential miRNA-mRNA pairs, provided candidate targets for studying high-proli cacy traits in sheep. As study showed, estrogen receptor (ESR) gene was related to litter traits [41]. Among these miRNA-mRNA pairs, the core genes ESR1 was identi ed the target of miRNAs unconservative_NC_019472.2_1229533 and unconservative_NC_019481.2_1637827.…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

Dong

Jiang

Liu

et al. 2023

Preprint

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Background MicroRNAs (miRNAs) play an important regulatory role in mammalian reproduction. Currently, most studies are primarily concentrated on ovarian miRNAs, ignoring the influence of uterine miRNAs on the fecundity of female sheep. To uncover potential regulators of sheep fecundity, RNA-seq was used to comparatively analyze miRNA expression profiles of endometrium between high prolificacy sheep (HP, litter size = 3) and low prolificacy sheep (LP, litter size = 1) with FecBB genotype. Results Firstly, genomic features of miRNAs from endometrium were analyzed. Furthermore, 58 differentially expressed (DE) miRNAs were found in the endometrium of Hu sheep with different litter size. A co-expression network of DE miRNAs and target genes has been constructed, and hub genes related litter size are included, such as DE miRNA unconservative_NC_019472.2_1229533 and unconservative_NC_019481.2_1637827 target to ESR1 and unconservative_NC_019481.2_1637827 targets to TCF7. Moreover, functional annotation analysis showed that the target genes (NRCAM and NEGR1) of the DE miRNAs were significantly enriched in cell adhesion molecules (CAMs) signaling pathway, which was related to uterine receptivity. Conclusion Taken together, this study provides a new valuable resource for understanding the molecular mechanisms underlying Hu sheep prolificacy.

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“…In order to analysis roles of DE miRNAs, RNA-seq were used to identify the potential miRNA-mRNA pairs, provided candidate targets for studying high-prolificacy traits in sheep. As study showed, estrogen receptor (ESR) gene was related to litter traits [ 46 ]. Among these miRNA-mRNA pairs, the core genes ESR1 was identified the target of miRNAs unconservative_NC_019472.2_1229533 and unconservative_NC_019481.2_1637827.…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

Dong,

Jiang,

Liu

et al. 2023

BMC Genomics

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Background MicroRNAs (miRNAs) play an important regulatory role in mammalian reproduction. Currently, most studies are primarily concentrated on ovarian miRNAs, ignoring the influence of endometrial miRNAs on the fecundity of female sheep. To uncover potential regulators of sheep fecundity, RNA-seq was used to comparatively analyze miRNA expression profiles of endometrium between high prolificacy sheep (HP, litter size = 3) and low prolificacy sheep (LP, litter size = 1) with FecB genotype. Results Firstly, genomic features of miRNAs from endometrium were analyzed. Furthermore, 58 differentially expressed (DE) miRNAs were found in the endometrium of Hu sheep with different litter size. A co-expression network of DE miRNAs and target genes has been constructed, and hub genes related litter size are included, such as DE miRNA unconservative_NC_019472.2_1229533 and unconservative_NC_019481.2_1637827 target to estrogen receptor α (ESR1) and unconservative_NC_019481.2_1637827 targets to transcription factor 7 (TCF7). Moreover, functional annotation analysis showed that the target genes (NRCAM and NEGR1) of the DE miRNAs were significantly enriched in cell adhesion molecules (CAMs) signaling pathway, which was related to uterine receptivity. Conclusion Taken together, this study provides a new valuable resource for understanding the molecular mechanisms underlying Hu sheep prolificacy.

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Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs

Cited by 5 publications

References 14 publications

Effect of SNPs on Litter Size in Swine

Effect of SNPs on Litter Size in Swine

Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

Identification and analysis of differentially expressed microRNAs in endometrium to explore the regulation of sheep fecundity

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