Abstract:Gene expression from bulk RNA-seq studies is an average measurement between two chromosomes and across cell populations. Both allelic and cell-to-cell heterogeneity in gene expression results from promoter bursting patterns that repeatedly alternate between an activated and inactivated state. Increased cell-to-cell heterogeneity in gene expression has been shown as a hallmark of aging, which is potentially induced by the change of promoter bursting patterns. Despite their importance in humans, bursting kinetic… Show more
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