Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

Gyan, Ben; Goka, Bamenla; Cvetkovic, Jasmina Trifunovic; Kurtzhals, Jørgen A. L.; Adabayeri, Victoria; Perlmann, Hedvig; Lefvert, Ann‐Kari; Akanmori, Bartholomew D.; Troye‐Blomberg, Marita

doi:10.1111/j.1365-2249.2004.02590.x

Cited by 52 publications

(44 citation statements)

References 38 publications

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“…The VNTR polymorphism of the IL-4 gene was detected by the PCR method followed by agarose gel electrophoresis (Gyan et al, 2004). Figure 1 shows the VNTR polymorphism in intron 2 of the IL-1RN gene.…”

Section: Resultsmentioning

confidence: 99%

Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients

Ramachandran

Norhasniza²,

Patimah³

2011

Genet. Mol. Res.

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ABSTRACT. Variable number of tandem repeats (VNTR) polymorphism in the interleukin 4 (IL-4) gene has been associated with endstage renal disease (ESRD) subjects in many different populations, although with conflicting results. We determined the 70 bp of VNTR polymorphism at intron 3 of the IL-4 gene in Malaysian ESRD subjects. Buccal cells were collected from 160 case and 160 control subjects; genomic DNA was amplified using PCR, followed by agarose gel electrophoresis. There were significant differences in genotypes and alleles of the IL-4 gene. We conclude that VNTR polymorphism of the IL-4 gene is a risk factor for the development of ESRD among Malaysians.

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Section: Resultsmentioning

confidence: 99%

Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients

Ramachandran

Norhasniza²,

Patimah³

2011

Genet. Mol. Res.

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“…4 Several groups have investigated some polymorphisms of candidate genes that are located within chromosome 5q31-q33. Polymorphisms of IL4, IL12B and IL13 have been associated with severe malaria, [5][6][7] whereas the IL4-590T allele has been associated with infection prevalence, but not with parasitemia. 8 Moreover, IRF-1 polymorphisms that influence the expression of both IL4 and IL12B were associated with carriage of P. falciparum infection and severe malaria.…”

Section: Introductionmentioning

confidence: 99%

IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso

et al. 2008

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Chromosome 5q31-q33 has been linked to Plasmodium falciparum parasitemia in several independent studies. This chromosomal region contains numerous immunoregulatory genes. Among these, IL12B that encodes the p40 subunit of interleukin-12 (IL-12) appeared to be a promising functional candidate gene, and IL12Bpro, a promoter polymorphism, was associated with mortality from severe malaria in children. In this study, we characterized genetic variation in IL12B in 215 individuals belonging to 34 families and evaluated linkage and association of parasitemia with IL12B polymorphisms and haplotypes. We searched for IL12B polymorphisms in the coding regions and the corresponding intron-exon borders. We also examined IL12Bpro and IL12B 3 0 untranslated region (UTR) polymorphisms, which are thought to influence the production of IL-12. We showed a high level of conservation of IL12B-coding regions and identified five polymorphisms in introns and the two polymorphisms in the promoter and the 3 0 UTR regions. Although IL12B polymorphisms were linked to parasitemia, there was association of parasitemia with neither polymorphisms nor haplotypes. We cannot exclude that an unknown IL12B cis-regulatory element polymorphism affects both IL-12 production and parasitemia. However, our results suggest that genetic variation in IL12B does not explain differences in parasitemia in individuals living in an endemic area.

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“…Specifically, the Fulani tribe is much less prone to disease than other ethnic groups inhabiting Burkina Faso in West Africa. These genetic differences are not caused by a mutation in haemoglobin or in the HLA genes, but by as yet unknown loci; with IL-4 being a possible candidate [62].…”

Section: Plasmodium Sspmentioning

confidence: 99%

Infectious disease — a genetic view

Jarošíková

2011

Open Life Sciences

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Genetic analysis of resistance to infectious disease reveals many important cues that have led to new insights into the interaction between pathogen and host. This knowledge might help with a better prognosis for diseases, and to the development of novel therapeutics. This review focuses on genes and loci that control susceptibility to diseases with an important epidemiologic impact, such as AIDS, hepatitis B, gastritis and peptic ulcer, tuberculosis, leprosy, malaria, schistosomiasis and leishmaniasis. New perspectives for the integration of human and mouse genetics that contribute greatly to our understanding of regulatory mechanisms in health and disease, are also discussed.

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Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

Cited by 52 publications

References 38 publications

Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients

Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients

IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso

Infectious disease — a genetic view

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