Allelic frequencies of 13 STR loci in autochthonous Basques from the province of Vizcaya (Spain)

Pérez-Miranda, A.M.; Alfonso‐Sánchez, Miguel Á.; Kalantar, Arif; Peña, José A.; Pancorbo, Marian M. de; Herrera, René J.

doi:10.1016/j.forsciint.2004.09.118

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…STRs have become one of the most widely used genomic markers in several fi elds, including genetic mapping, linkage analysis and human identity testing, due to their hypervariable nature. This feature makes STRs valuable markers in molecular taxonomic studies with evolutionary perspective and in the elucidation of human population history [10][11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Qatari DNA Variation at a Crossroad of Human Migrations

et al. 2006

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Genomic diversity of the Qatari population was investigated by screening 15 autosomal short tandem repeats (STRs). Significant departures from genetic equilibrium were detected at the D13S317, D19S433 and VWA loci, which persisted after applying Bonferroni-type corrections. Gene diversity (GD) values ranged from 0.6851 (TPOX) to 0.8813 (D2S1338), while observed heterozygosity (Ho) oscillated between 0.3388 (D19S433) and 0.8397 (D2S1338). Interestingly, Ho was lower than expected (He) for 14 of the loci analyzed. The information provided by these microsatellite markers was analyzed by means of genetic distances, multidimensional scaling, hierarchical analyses of the molecular variance (AMOVA) and admixture estimations to assess the genetic relationships of Qatar with European, Asian, African and other Middle Eastern populations. The main findings of the study were the genetic uniqueness of the Qatari population, its strong similarity to the United Arab Emirates (UAE) group, a slight genetic differentiation with respect to other Arab populations (Syria and Egypt) and Turkey, and a certain genetic affinity with sub-Saharan African populations. These results are discussed in light of two major issues: the high consanguinity rates characterizing the Qatari population and its strategic geographic position in the Arabian Peninsula close to major migratory routes, an important pivotal contact zone for bidirectional dispersals between Eurasia and Africa.

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Section: Introductionmentioning

confidence: 99%

Qatari DNA Variation at a Crossroad of Human Migrations

et al. 2006

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“…These STRs constitute the core of PCR-based genetic markers in the US-combined DNA index system (CODIS). In addition, STR allelic frequency data previously reported by our research team from two Basque groups from the provinces of Alava and Vizcaya were included in our analyses to augment the geographical scope of our study (Pe´rez-Miranda et al 2005a, 2005b. Finally, for the purposes of assessing population affinities and phylogenetic relationships with other human groups, European (including Spain), North African, and Middle Eastern populations were jointly analyzed.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite data support subpopulation structuring among Basques

et al. 2005

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Genomic diversity based on 13 short tandem repeat (STR) loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, and CSF1PO) is reported for the first time in Basques from the provinces of Guipu´zcoa and Navarre (Spain). STR data from previous studies on Basques from Alava and Vizcaya provinces were also examined using hierarchal analysis of molecular variance (AMOVA) and genetic admixture estimations to ascertain whether the Basques are genetically heterogeneous. To assess the genetic position of Basques in a broader geographic context, we conducted phylogenetic analyses based on F ST genetic distances [neighbor-joining trees and multidimensional scaling (MDS)] using data compiled in previous publications. The genetic profile of the Basque groups revealed distinctive regional partitioning of short tandem repeat (STR) diversity. Consistent with the above, native Basques clearly segregated from other populations from Europe (including Spain), North Africa, and the Middle East. The main line of genetic discontinuity inferred from the spatial variability of the microsatellite diversity in Basques significantly overlapped the geographic distribution of the Basque language. The genetic heterogeneity among native Basque groups correlates with the peculiar geography of peopling and marital structure in rural Basque zones and with language boundaries resulting from the uneven impact of Romance languages in the different Basque territories.

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“…(STRs) represents hypervariable regions that can provide the fine resolution needed to determine relationships among closely related populations in recent evolutionary history (Bowcock et al 1994;Jorde et al 1995Jorde et al , 1997Bosch et al 2000;Lum et al 2002;Rowold and Herrera 2003;Pérez-Miranda et al 2005;Shepard and Herrera 2005) and the discrimination power essential for robust individual probabilities of inclusion (Leibelt et al 2003;Collins et al 2004). Also, STRs are used in these studies because of their numerous and relatively even distribution throughout the genome, high levels of polymorphism, a large number of possible alleles per locus, and short amplicon lengths, which facilitate DNA amplification, separation, and detection (Butler 2001;Butler et al 2003).…”

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Autosomal STR Variation in Five Austronesian Populations

Shepard¹,

Chow²,

Suafo'a³

et al. 2005

Human Biology

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Human population characteristics at the genetic level are integral to both forensic biology and population genetics. This study evaluates biparental microsatellite markers in five Austronesian-speaking groups to characterize their intra-and interpopulation differences. Genetic diversity was analyzed using 15 short tandem repeat (STR) loci from 338 unrelated individuals from 5 Pacific islands populations, including the aboriginal Ami and Atayal groups from Taiwan, Bali and Java in Indonesia, and the Polynesian islands of Samoa. Allele frequencies from the STR profiles were determined and compared to other geographically targeted worldwide populations procured from recent literature. Hierarchical AMOVA analysis revealed a large number of loci that exhibit significant correspondence to linguistic partitioning among groups of populations. A pronounced divide exists between Samoa and the East (Formosa) and Southeast Asian (Bali and Java) islands. This is clearly illustrated in the topology of the neighbor-joining tree. Phylogenetic analyses also indicate clear distinctions between the Ami and Atayal and between Java and Bali, which belie the respective geographic proximities of the populations in each set. This differentiation is supported by the higher interpopulation variance components of the Austronesian populations compared to other Asian non-Austronesian groups. Our phylogenetic data indicate that, despite their linguistic commonalities, these five groups are genetically distinct. This degree of genetic differentiation justifies the creation of population-specific databases for human identification.Genetic diversity, characterized at both the intra-and the interpopulation level, forms the basis of forensic biology and population genetics, respectively. Yet these two disciplines are not always fully integrated in studies using human samples. A well-established marker system such as autosomal short tandem repeats

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Allelic frequencies of 13 STR loci in autochthonous Basques from the province of Vizcaya (Spain)

Cited by 11 publications

References 16 publications

Qatari DNA Variation at a Crossroad of Human Migrations

Qatari DNA Variation at a Crossroad of Human Migrations

Microsatellite data support subpopulation structuring among Basques

Autosomal STR Variation in Five Austronesian Populations

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