Allelic Frequencies and Patterns of Single-nucleotide  Polymorphisms in Candidate Genes for Asthma and  Atopy in Iceland

Hákonarson, Hákon; Björnsdóttir, Unnur Steina; Ostermann, Elínborg; Arnason, T. J.; Adalsteinsdottir, Asdis E.; Halapi, Eva; Shkolny, Dana; Kristjánsson, Kristleifur; Gudnadottir, Sigurbjorg A.; Frigge, Michael L.; Gíslason, Davíð; Gíslason, Þórarinn; Kong, Augustine; Gulcher, Jeffrey R.; Stefánsson, Kāri

doi:10.1164/ajrccm.164.11.2101086

Cited by 84 publications

(54 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the TT genotype has been associated with an increased risk of asthma in some studies (13,17,20) but not in others (21,32). We found that the CC and CT genotypes of SNP rs1800469 (which were correlated with relatively reduced circulating levels of TGF-b1 in two of three previous studies [ Table 1]) were associated with increased airway responsiveness.…”

Section: Discussionmentioning

confidence: 46%

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Sharma¹,

Raby²,

Hunninghake³

et al. 2009

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Polymorphisms in the gene for transforming growth factor-b1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma. Objectives: To test for association between single nucleotide polymorphisms (SNPs) in TGFB1 and markers of asthma severity in childhood. Methods: We tested for the association between nine SNPs in TGFB1 and indicators of asthma severity (lung function, airway responsiveness, and disease exacerbations) in two cohorts: 416 Costa Rican parent-child trios and 465 families of non-Hispanic white children in the Childhood Asthma Management Program (CAMP). We also tested for the interaction between these polymorphisms and exposure to dust mite allergen on asthma severity. Measurements and Main Results: The A allele of promoter SNP rs2241712 was associated with increased airway responsiveness in Costa Rica (P 5 0.0006) and CAMP (P 5 0.005), and the C allele of an SNP in the promoter region (rs1800469) was associated with increased airway responsiveness in both cohorts (P < 0.01). Dust mite exposure modified the effect of the C allele of exonic SNP rs1800471 on airway responsiveness (P 5 0.03 for interactions in both cohorts). The T allele of a coding SNP (rs1982073) was associated with a reduced risk of asthma exacerbations in Costa Rica (P 5 0.009) and CAMP (P 5 0.005). Dust mite exposure also significantly modified the effect of the A allele of the promoter SNP rs2241712 on asthma exacerbations in both cohorts. Conclusions: SNPs in TGFB1 are associated with airway responsiveness and disease exacerbations in children with asthma. Moreover, dust mite exposure may modify the effect of TGFB1 SNPs on airway responsiveness and asthma exacerbations.

show abstract

Section: Discussionmentioning

confidence: 46%

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Sharma¹,

Raby²,

Hunninghake³

et al. 2009

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…In 2000, Fryer et al [11] first reported the positive association of a single-nucleotide polymorphism [SNP; 342A→G (Ile105Val); rs1695] of GSTP1 with bronchial hyperresponsiveness, skin pick test and asthma. Subsequently, a positive association of this SNP with asthma was reported in Turkish [12, 13] and Taiwanese [14, 15] populations, and a negative association was reported in Icelandic [16] and Russian [17] populations. An association of this SNP with disease susceptibility and gene environmental interaction were also reported in childhood [15, 18] and occupational asthma [19, 20].…”

Section: Introductionmentioning

confidence: 99%

The GSTP1 Gene Is a Susceptibility Gene for Childhood Asthma and the GSTM1 Gene Is a Modifier of the GSTP1 Gene

Kamada¹,

Mashimo

Inoue

et al. 2007

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Bronchial asthma is a chronic airway disorder characterized by bronchial inflammation. Oxidative stress is a key component of inflammation. Glutathione S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferases (GSTs) in lung epithelium, plays a key role in cellular protection against oxidative stress. Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily. Methods: We screened single-nucleotide polymorphisms (SNPs) at the GSTP1 locus and performed an association study in the Japanese population using two independent case-control groups (group 1: 391 pediatric patients with asthma, 462 adult patients with asthma, and 639 controls, and group 2: 115 pediatric patients with asthma and 184 controls). The effect of GSTM1 null/present genotype on the association between GSTP1 Ile105Val and asthma was also investigated. Results: We identified 20 SNPs at this locus and found this region consisted of one linkage disequilibrium block represented by four SNPs (tag SNPs). The association between the Ile105Val polymorphism in the GSTP1 gene and childhood asthma was significant in both groups (p = 0.047 in group 1, and p = 0.021 in group 2). This association was only significant in patients with GSTM1-positive genotype in both groups (group 1: GSTM1 present p = 0.013 and GSTM1 null p = 0.925, and group 2: GSTM1 present p = 0.015 and GSTM1 null p = 0.362). Conclusions: These findings suggest that the GSTP1 gene is a childhood asthma susceptible gene, and the GSTM1 gene is a modifier gene of GSTP1 for the risk of childhood asthma in the Japanese population.

show abstract

“…For example, in 2001, deCODE genetics (Reykjavik, Iceland) published the finding that 42 SNPs within 24 ''asthma genes'' did not differ between cases and controls (3). Because only 94 cases and controls were studied, they could only conclude that those mutations were unlikely to incur odds ratios (ORs) greater than 2.…”

mentioning

confidence: 99%

Assessing the Reproducibility of Asthma Candidate Gene Associations, Using Genome-wide Data

Rogers

Raby²,

Lasky‐Su³

et al. 2009

Am J Respir Crit Care Med

101

View full text Add to dashboard Cite

Allelic Frequencies and Patterns of Single-nucleotide Polymorphisms in Candidate Genes for Asthma and Atopy in Iceland

Cited by 84 publications

References 68 publications

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

Variants in TGFB1, Dust Mite Exposure, and Disease Severity in Children with Asthma

The <i>GSTP1</i> Gene Is a Susceptibility Gene for Childhood Asthma and the <i>GSTM1</i> Gene Is a Modifier of the <i>GSTP1</i> Gene

Assessing the Reproducibility of Asthma Candidate Gene Associations, Using Genome-wide Data

Contact Info

Product

Resources

About