Allelic exclusion in anamniotic vertebrates

Hsu, Ellen; Lee, Susan S.

doi:10.1006/smim.1999.0189

Seminars in Immunology

1999

DOI: 10.1006/smim.1999.0189

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Allelic exclusion in anamniotic vertebrates

Ellen Hsu

Susan S. Lee

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Cited by 2 publications

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“…The principle of clonal selection suggests that only one allele is used at loci encoding antigen receptors [ 8 ]. However, this study detected the presence of multiple α or β chains in a single T cell.…”

mentioning

confidence: 99%

A new immunological index for the elderly: high proportion of multiple TCR T cells based on scRNA-seq

2023

Aging dis

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mentioning

confidence: 99%

A new immunological index for the elderly: high proportion of multiple TCR T cells based on scRNA-seq

2023

Aging dis

View full text Add to dashboard Cite

The plasticity of immunoglobulin gene systems in evolution

Hsu

Pulham

Rumfelt

et al. 2006

Immunological Reviews

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SummaryThe mechanism of recombination-activating gene (RAG)-mediated rearrangement exists in all jawed vertebrates, but the organization and structure of immunoglobulin (Ig) genes, as they differ in fish and among fish species, reveal their capability for rapid evolution. In systems where there can exist 100 Ig loci, exon restructuring and sequence changes of the constant regions led to divergence of effector functions. Recombination among these loci created hybrid genes, the strangest of which encode variable (V) regions that function as part of secreted molecules and, as the result of an ancient translocation, are also grafted onto the T-cell receptor. Genomic changes in V-gene structure, created by RAG recombinase acting on germline recombination signal sequences, led variously to the generation of fixed receptor specificities, pseudogene templates for gene conversion, and ultimately to Ig sequences that evolved away from Ig function. The presence of so many Ig loci in fishes raises interesting questions not only as to how their regulation is achieved but also how successive wholelocus duplications are accommodated by a system whose function in other vertebrates is based on clonal antigen receptor expression.

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Allelic exclusion in anamniotic vertebrates

Cited by 2 publications

References 40 publications

A new immunological index for the elderly: high proportion of multiple TCR T cells based on scRNA-seq

A new immunological index for the elderly: high proportion of multiple TCR T cells based on scRNA-seq

The plasticity of immunoglobulin gene systems in evolution

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