Allelic distribution of <i>ABO</i> gene in Chinese centenarians

Ying, Zhu; Khan, Abdul Haseeb; Dong, Minghua; Wan, Yiqi; Sun, Zhichao; Zeng, Yi; Nie, Chao; Tian, Xiao-Li

doi:10.1002/agm2.12122

Cited by 2 publications

(2 citation statements)

References 47 publications

(101 reference statements)

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“…In contrast, a recent study conducted on a large Chinese cohort suggested that blood types and SNPs (rs507666, rs8176746, etc.) were not associated with lifespan 31 . In our study cohort, although antigen A carriers did not exhibit a significantly longer OS, their PFS was significantly longer than that of patients without antigen A, suggesting its potential protective role.…”

Section: Discussioncontrasting

confidence: 59%

“…were not associated with lifespan. 31 In our study cohort, although antigen A carriers did not exhibit a significantly longer OS, their PFS was significantly longer than that of patients without antigen A, suggesting its potential protective role. Despite the absence of a discernible protective role of antigen A on OS, the potential for identifying more significant OS differences could be realized with extended follow-up periods and an expanded sample size.…”

Section: Discussionmentioning

confidence: 47%

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Blood Group Antigen A Carriers Exhibit an Extended Progression‐Free Survival with no more Immune‐Related Adverse Events

Xiao,

Liu,

Luo

et al. 2023

Clin Pharma and Therapeutics

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Extensive investigations have been conducted regarding the potential correlation between blood type and the immune system, as well as cancer risk in the Southern Chinese population. However, the prognostic value of the blood group and its genetic determinants in the context of immune checkpoint inhibitor (ICI) treatment remains unclear. Therefore, the associations between the ABO blood group and its single nucleotide polymorphisms (SNPs) were examined in relation to ICI treatment outcomes in 370 eligible patients with cancer. This approach allowed us to derive the blood group from the SNPs responsible for blood group determination. In the discovery cohort (N = 168), antigen A carriers (blood types A and AB) exhibited an extended progression‐free survival (PFS; hazard ratio (HR) = 0.58, 95% confidence interval (CI) = 0.34–0.98). The association results from the SNP‐derived blood were consistent with those from the measured blood group. In the validation cohort (N = 202), Cox regression analysis revealed that the antigen A carriers (rs507666 AA+GA genotype carriers) experienced significantly extended PFS compared with the non‐antigen A carriers (HR = 0.61, 95% CI = 0.40–0.93). Therefore, a longer PFS was observed in antigen A carriers (P value = 0.003, HR = 0.60, 95% CI = 0.44–0.84). Furthermore, haplotype 2 carriers (rs507666 GA and rs659104 GG) demonstrated both extended PFS and improved overall survival. Notably, the presence of antigen A was not associated with the occurrence of overall immune‐related adverse events (irAEs) or organ‐specific toxicity. In summary, our findings revealed that antigen A carriers did not experience a higher incidence of irAEs while exhibiting better immunotherapy efficacy.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 47%

Blood Group Antigen A Carriers Exhibit an Extended Progression‐Free Survival with no more Immune‐Related Adverse Events

Xiao,

Liu,

Luo

et al. 2023

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

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A Misconception About the Hardy–Weinberg Law

Stark

2021

Twin Res Hum Genet

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The Hardy–Weinberg law of population genetics is usually associated with the notion of random mating of parents. A numerical example for a triallelic autosomal locus shows that an uncountable set of mating combinations can maintain Hardy–Weinberg proportions. Therefore, one cannot infer random mating in a population from the observation of Hardy–Weinberg equilibrium. The mating system which ensures that the genotypic distribution of offspring is the same as that of the parents is specified.

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Allelic distribution of ABO gene in Chinese centenarians

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 47 publications

Blood Group Antigen A Carriers Exhibit an Extended Progression‐Free Survival with no more Immune‐Related Adverse Events

Blood Group Antigen A Carriers Exhibit an Extended Progression‐Free Survival with no more Immune‐Related Adverse Events

A Misconception About the Hardy–Weinberg Law

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