Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes

Lv, Ke; Guo, Yingjun; Zhang, Yiliang; Wang, Kaiyu; Yin, Jianfei; Sun, Shuhan

doi:10.1016/j.bbrc.2008.06.102

Cited by 50 publications

(36 citation statements)

References 24 publications

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“…These five miRNAs might also serve as oncogenic modulators. In addition, miR-657 and miR-208 are implicated in other diseases, such as type II diabetes (miR-657) (Lv et al, 2008). In particular, miR-208, a cardiac-specific miRNA, is required for cardiomyocyte hypertrophy (van Rooij et al, 2007).…”

Section: Comparisons Of Target-prediction Toolsmentioning

confidence: 99%

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

et al. 2010

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Cyclin-dependent kinase inhibitor 1A (CDKN1A), also known as p21Cip1/Waf1, is a master downstream effector of tumor suppressors. In this study, we experimentally demonstrate through a high-throughput luciferase reporter screen that p21Cip1/Waf1 can be directly targeted by nearly 28 microRNAs (miRNAs). The results were further confirmed by a series of mutational analyses and luciferase reporter assays. These 28 miRNAs can substantially inhibit p21Cip1/Waf1 expression, predominantly at translational level. Many of these miRNAs were upregulated in cancers and might serve as modulators of oncogenesis. Furthermore, 8 of these 28 p21-regulating miRNAs are located in the chromosome 19 miRNA cluster, the largest miRNA gene cluster in humans, and they can clearly promote cell proliferation and cell-cycle progression in choriocarcinoma cells. In conclusion, our screening strategy provides an alternative approach to uncovering miRNA modulators of an individual mRNA, and it has identified multiple miRNAs that can suppress p21Cip1/Waf1 expression by directly targeting its 3 0 untranslated region.

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Section: Comparisons Of Target-prediction Toolsmentioning

confidence: 99%

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

et al. 2010

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“…Values with the same letters indicate that no significant differences were found between the groups. AST, aspartate aminotransferase; ALT, alanine aminotransferase; DBP, diastolic blood pressure; EMA, early menarche age; FBG, fasting blood glucose; Hb1Ac, glycated hemoglobin 1ac; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; LDL-C, low-density lipoprotein cholesterol; LMA, late menarche age; NMA, normal menarche age; SBP, systolic blood pressure; TC, total cholesterol; TG, triglycerides [34], which contributes to the development of diabetes [35]. During the preparation of this manuscript, two studies have just reported in Korea which found inverse association between early age at menarche and diabetes.…”

Section: Odds Ratios (Ors) For Diabetes By Age At Menarchementioning

confidence: 99%

Association between age at menarche and diabetes in Korean post-menopausal women: results from the Korea National Health and Nutrition Examination Survey (2007-2009)

et al. 2015

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POST-MENOPAUSAL women are highly exposed to multiple health problems and risk of diabetes is higher in postmenopausal women than in their pre-menopausal counterparts [1]. Diabetes decrease healthrelated quality of life because of diabetic complications, and increase burden of disease [2]. Considering the fact that diabetes-caused death rate per 100,000 is 37.5 in women aged 50-69 years and 186.9 in women aged 70-80 years, whereas 2.7 in women aged 15-49 years, prevention and treatment for diabetes are an important health issue for post-menopausal women [3].Age at menarche is defined as the age at the onset of menstruation in adolescents and is frequently used Abstract. Early menarche is known to be associated with diabetes, however this association remains controversial. Our study aimed to investigate the possible association between age at menarche and diabetes prevalence in post-menopausal Korean women. This study included 3,254 post-menopausal Korean women aged 50-85 years from the Korea National Health and Nutrition Examination Survey IV (KNHANES 2007(KNHANES -2009). Logistic regression analyses were used to estimate odds ratios (ORs) for diabetes prevalence. Levels of biochemical markers were compared according to groups by age at menarche. Women in the earlier menarche age group (10-12 years) showed higher levels of fasting blood glucose (FBG) and scores of homeostatic model assessment in the insulin resistance (HOMA-IR) index than other groups (p <0.05). After adjusting for potential confounding factors, early age at menarche was significantly associated with a higher prevalence of diabetes (OR 1.86, 95% confidence intervals [CI] 1.07-3.23). The observed association remained significant despite additional adjustment for body mass index and waist circumference (OR 1.82, 95% CI 1.03-3.23) and despite further adjustments for FBG levels and HOMA-IR index (OR 2.25, 95% CI 1.11-4.55). Our findings strengthen the hypothesis that younger age at menarche is associated with increased diabetes prevalence in the Korean population.

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“…41 Such genetic variation have the potential to either affect the efficiency of miRNA binding on its target site, create or destroy binding sites, which ultimately result in gene dysregulation that can involve changes in phenotype and be eventually critical as to the susceptibility or the onset of diseases. Gene dysregulation caused due to SNPs in miRNA target sites and their association with diseases have been reported in diseases, such as cancers, 42,43 diabetes, 44 cardiovascular diseases, 45 neurodegenerative diseases. 46,47 The genetic variability…”

Section: Resultsmentioning

confidence: 99%

A complex crosstalk between polymorphic microRNA target sites and AD prognosis

Mallick

Ghosh²

2011

RNA Biology

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Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes

Cited by 50 publications

References 24 publications

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

Association between age at menarche and diabetes in Korean post-menopausal women: results from the Korea National Health and Nutrition Examination Survey (2007-2009)

A complex crosstalk between polymorphic microRNA target sites and AD prognosis

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