“…In contrast, there are many differences in the corresponding residues between chicken LILRA2 and group 1 of LILRs in human D1–D2 region, explaining LILRA2 in chicken and human likely do not bind to MHC molecules. On the other hand, human LILRA6 (group 2 of LILRs) amino acids associated with MHC class I and β2m ligand binding (S 17 , G 19 , Q/R 36 , G 41 , L/W 46 , Q/E 67 , Y 77 , T 97 , S 101 , T 117 , R/Q 120 , N/T 160 , M/T 178 and Q/W/R 182 ) in Ig domain D1–D2, in which the Ig D1 region (S 17 , G 19 , Q/R 36 , G 41 , L/W 46 , Q/E 67 , Y 77 and T 97 ) strongly bind to MHC class I and β2m [ 5 , 10 , 24 ] that are highly conserved in chicken and human LILRA6. The results indicated that Ig D1 region of LILRA6 is strongly binds to MHC class I but LILRA2 does not bind to MHC class I and β2m.…”