Allele Frequency of the CCR5 Mutant Chemokine Receptor in Greek Caucasians

Nasioulas, Georgios; Dean, Michael; Koumbarelis, E.; Paraskevis, Dimitrios; Gialeraki, A.; Karafoulidou, Anastasia; Mandalaki, T.; Hatzakis, Angelos

doi:10.1097/00042560-199802010-00015

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…In the group of HIV‐positive individuals no mutant homozygous genotypes were found. These results are consistent with the CCR5 allele frequencies previously found in a separate group of Greek Caucasians [6]. The frequency of the CCR5Δ 32 allele among HIV‐negative subjects in Greece (0.052) is in the mid range of the values observed in Northern Europe (∼0.09) and those observed in Cyprus (0.029) [7].…”

Section: Resultssupporting

confidence: 91%

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

Papa

Papadimitriou

Adwan

et al. 2000

FEMS Immunology &Amp; Medical Microbiology

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The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.

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Section: Resultssupporting

confidence: 91%

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

Papa

Papadimitriou

Adwan

et al. 2000

FEMS Immunology &Amp; Medical Microbiology

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show abstract

“…In the group of HIV-positive individuals no mutant homozygous genotypes were found. These results are consistent with the CCR5 allele frequencies previously found in a separate group of Greek Caucasians [6]. The frequency of the CCR5v32 allele among HIV-negative subjects in Greece (0.052) is in the mid range of the values observed in Northern Europe (V0.09) and those observed in Cyprus (0.029) [7].…”

Section: Resultssupporting

confidence: 91%

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

Papa¹

2000

FEMS Immunology and Medical Microbiology

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“…Although individuals with homozygous ¢ccr-5 genotypes have been determined to be strongly protected from sexual infection [33], the homozygous genotype does not offer complete protection [37]. In heterozygous adults, the protective effect concerning HIV-1 infection is seen by as much as a twofold lower infection rate for heterozygous CCR5/¢ccr5 adults than wildtype CCR5/CCR5 [32,35,38,39]. Similarly, some data have determined that heterozygous infants have some protection from vertical transmission infection, although not as much as adult protection from sexual infection [35,40], while others suggest there is no correlation between heterozygous genotype and protection from infection by vertical transmission [34,36,41,42].…”

Section: Timing Of Vertical Transmissionmentioning

confidence: 99%

Immunopathological Factors for Vertical Transmission of HIV-1

Edgeworth¹,

Ugen²

2000

Pathobiology

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With the global rise in human immunodeficiency virus-1 (HIV-1) infection in women of childbearing age, there has also been an alarming rise in the number of mother-to-child transmissions of HIV-1. Although drug therapies such as zidovudine as well as nevirapine have been demonstrated to significantly decrease the incidence of vertical transmission of HIV-1, these therapeutic regimens are still not widely available in some developing countries where maternal-to-child transmission of HIV-1 continues to occur at an alarming rate. Therefore, the continued studies of mechanisms and correlates of vertical transmission of HIV-1 are warranted. The current status of immunological and virological correlates of vertical transmission are summarized in this review. In addition, information concerning recent therapeutic agents for the prevention of HIV-1 vertical transmission is presented.

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Allele Frequency of the CCR5 Mutant Chemokine Receptor in Greek Caucasians

Cited by 6 publications

References 16 publications

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks

Immunopathological Factors for Vertical Transmission of HIV-1

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