Allele frequency estimates when only heterozygotes can be recognized: method of estimation and application in the case of chromosomal inversion polymorphisms in Drosophila

Klaczko, Louis Bernard; Otto, Paulo Alberto; Peixoto, Alexandre A.

doi:10.1038/hdy.1990.32

Cited by 5 publications

(8 citation statements)

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“…In contrast, proximal inversions are rather difficult to recognize in different homozygotes (Klaczko et al, 1990). Since the linkage disequilibrium between the distal and proximal inversions is very strong in D. mediopunctata (see Peixoto and Klaczko, 1991), we used the distal inversions DA, DI, DS, DP, and DV as genetic markers for the haplotypes DA-PA0, DI-PB0, DS-PC0, DP-PC0, and DV-PC0, which together represent more than 85% of the total number of haplotypes.…”

Section: Discussionmentioning

confidence: 99%

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Chromosomal inversion polymorphism in Drosophila mediopunctata: seasonal, altitudinal, and latitudinal variation

Ananina

Peixoto²,

Bitner‐Mathé

et al. 2004

Genet. Mol. Biol.

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The most polymorphic chromosome for inversions in Drosophila mediopunctata is the chromosome II, where 17 inversions have been found, eight of which occurring in the distal region and nine in the proximal region. We present an analysis of the chromosome II inversion polymorphism with respect to seasonal, altitudinal and latitudinal variation. In D. mediopunctata from the Parque Nacional do Itatiaia (southeastern Brazil), the frequencies of three of the distal inversions (namely DA, DS, and DP) vary seasonally. These inversions also show altitudinal clines in their frequencies. This microgeographic pattern was not observed on a macrogeographic scale. D. mediopunctata from Porto Alegre are less polymorphic for inversions than other populations, the most remarkable reduction occurring in the proximal region of chromosome II. There is a considerable difference between D. mediopunctata from Campinas and specimens from Serra do Japi, which are separated by only 50 km. In contrast, D. mediopunctata from Serra do Japi are much more similar to specimens from the Parque Nacional do Itatiaia, which is 200 km far.

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Section: Discussionmentioning

confidence: 99%

“…1989; Klaczko et al, 1990;Peixoto and Klaczko, 1991). Chromosome II is the most polymorphic, with 17 inversions described.…”

Section: Introductionmentioning

confidence: 99%

Chromosomal inversion polymorphism in Drosophila mediopunctata: seasonal, altitudinal, and latitudinal variation

Ananina

Peixoto²,

Bitner‐Mathé

et al. 2004

Genet. Mol. Biol.

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“…On the other hand if one uses the 'egg sample method' all homozygotes can show up making it difficult to determine the inversion frequencies. However, we figured out that since there are more than two overlapping inversions ('alleles') in this region it is possible, using only the frequencies of the various heterozygotes and the total frequency of homozygotes, to estimate the frequency of each inversion using a maximum-likelihood method (Klaczko, Otto & Peixoto, 1990). When we compared our estimates using this method to the ones using the male method we obtained similar results, showing that it is reliable.…”

Section: Chromosome Inversionsmentioning

confidence: 99%

Evolutionary Genetics of Drosophila Mediopunctata

Klaczko

2006

Genetica

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Drosophila mediopunctata belongs to the tripunctata group, which is the second largest Neotropical group of Drosophila with 64 species described. Here I review the work done with this forest dwelling species, and some applications of the methods developed using it as a model organism, to other species. Specifically I look at: the phylogenetic status of the tripunctata group and its relation with other groups in the Hirtodrosophila-immigrans radiation; D. mediopunctata's chromosome inversion polymorphism (altitudinal cline of frequencies and evidences of selection); the morphological variation of the wing and the development and applications of the ellipse method to describe the morphology of the wing; the variation on the number of aristal branches; the genetic basis of the polychromatism present in D. mediopunctata and its association with chromosome inversions; the sex-ratio trait and its use in the demonstration of Fisher's principle; and, finally, the finding of the transposable P-element in this species.

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“…Chromosome X has four different gene arrangements, one of them associated to the "sex-ratio" phenomenon. Chromosome IV has only two gene arrangements (Carvalho et al 1989, Klaczko et al 1990, Peixoto & Klaczko 1991.…”

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confidence: 99%