Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study

Akay, Aynur Pekcanlar; Yazıcıoğlu, Çiğdem Eresen; Güney, Sevay Alşen; Erkuran, Handan Özek; Kızıldağ, Sefa; Baykara, Burak; Özyurt, Gonca; Kadıçeşme, Şebnem Yıldırımcan; Miral, Süha; Emiroğlu, Neslihan İnal

doi:10.1080/24750573.2017.1418134

Cited by 5 publications

(1 citation statement)

References 45 publications

(49 reference statements)

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“…DRD4 is functionally linked to the dopamine system's signal transmission, regulating executive functions such as control and inhibition of attention and action. The dopamine receptor gene D4 (DRD4) is mainly emphasized in the dopaminergic system, and research finds the gene Catechol-O-methyltransferase (COMT) is necessary in responding to treatment; Akay et al, 2018). NR3C1(glucocorticoid receptor): The axis of the hypothalamus-pituitary-adrenal gland (HPA Axis) controls the release and regulation of stress hormones and is closely linked to stress associated with physical and mental illness.…”

Section: Anti-anxiety Mechanism Co Active Compoundmentioning

confidence: 99%

Network Pharmacology Analysis of Cananga odorata as a Treatment for Anxiety Disorders

Maretha,

Jamil,

Rofida

et al. 2023

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Anxiety disorder is a psychological disorder associated with the existence of mental disorders and experiencing constant anxiety. In C. odorata, part of the flower has the potential as a sedative for the nervous system and for dealing with anxiety. The study aims to analyze the potential compound content in Cananga odorata for treating anxiety disorders with In silico-based pharmacological network analysis. CO compound data from the KNApSAck database, Absorption, Distribution, Metabolism, and Excretion (ADME) screening using SwissADME, predicted target proteins using Swiss Target Prediction, GeneCards, Venny, String DB pharmacological network analysis, Visualization with Cytoscape version 3.10.0, and Way2drug. The results of the pharmacological tissue analysis of the compound content in C. odorata obtained 45 compounds, and 18 known active components meet the criteria of Absorption, Distribution, Metabolism, and Excretion (ADME) that correspond to the drug compounder (Drug Likeness/DL). Based on the pathway that correlates with anxiety disorder therapy are the neurotransmitter systems like serotonin receptors and dopamine receptors. The known therapeutic target proteins are HTR1A, HTR2A, SLC6A4, NR3C1, MAOA, DRD4, HSP90AA1, JUN, ten active compounds associated with C. odorata namely Anonaine, (+)-Reticuline, linalool, (-)-Coreximine, Micheline A, (-)-Ushinsunine beta-N-oxide, 4-Terpineol, alpha-Terpeneol, Sampangine, Anaxagoreine. Based on the results of research, C. odorata is potentially a treatment for anxiety disorder.

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Section: Anti-anxiety Mechanism Co Active Compoundmentioning

confidence: 99%