Allele frequencies of 23 autosomal short tandem repeat loci in the Philippine population

Rodriguez, Jae Joseph Russell B.; Salvador, Jazelyn M.; Calacal, Gayvelline C.; Laude, Rita P.; Ungria, Maria Corazon A. De

doi:10.1016/j.legalmed.2015.02.005

Cited by 21 publications

(9 citation statements)

References 7 publications

(6 reference statements)

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“…The evidentiary DNA profile is only meaningful when compared to a known or reference profile. Generally, the weight of the evidence depends on the rarity of the profile estimated from a reference database of the relevant population [ 31 , 32 ]. To avoid possible confirmation bias, interpretation of DNA typing results from the evidence should be done before any comparison to a known profile except those assumed to be already present in the mixture (e.g.…”

Section: An Integrated System For Dna Testing In Sexual Assault Casesmentioning

confidence: 99%

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

Rodriguez

Laude

Ungria

2021

Forensic Science International: Synergy

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In the Philippines, more than 7000 cases of sexual assault are reported annually. DNA technology is a powerful tool in identifying assailants. However, it is not routinely used in sexual assault investigations due to insufficient government support to cover the high cost of DNA testing and the absence of a national system for sample collection, handling, storage, and DNA testing of biological evidence. In itself, the nature of sexual assault samples containing DNA mixtures presents challenges to laboratory methods and interpretation of results. The sample recovered from the victim may only contain trace amounts of the assailant’s DNA, may have degraded due to prolonged storage in ambient conditions which is warm and humid in the tropics, or contaminated with inhibitors, such as in anal swabs. Hence, a closer evaluation of the processes of evidence collection and DNA testing is needed to increase the likelihood of success in generating conclusive results. In this paper, we propose an integrated system for DNA testing of biological samples collected from sexual assault victims considering the limitations of resources and the prevailing warm climate. Recommendations in this work should provide basis for formulating national guidelines for DNA analysis in aid of criminal investigations. The proposed scheme can be adopted by forensic DNA laboratories in the Philippines and in other countries facing similar challenges.

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Section: An Integrated System For Dna Testing In Sexual Assault Casesmentioning

confidence: 99%

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

Rodriguez

Laude

Ungria

2021

Forensic Science International: Synergy

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“…In the 19 STR loci, VWA, FGA, Penta E locus were identi ed signi cant associations with drug abuser among Chinese Han ethnicity in our study. Because Penta E has the highest polymorphism information content (PIC), discrimination ability (PD) [26] and the most prone to mutation [27]. As well as, FGA and VWA sites are the most prone to change in size (p = 0.002) [28].…”

Section: Discussionmentioning

confidence: 99%

The Allele Frequency Variation of Autosomal 19 Short Tandem Repeat (STR) Loci in Drug Abuser: A Pilot Study

Lin¹,

Zhang²,

Su³

et al. 2020

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Backgrounds: Substance use disorders (SUDs) refers to drug abuse of 10 separate classes impacting seriously mental health.Objective: This study aims to explore the genetic polymorphism of the 19 short tandem repeat (STR) loci (D19S433, D5S818, D21S11, D18S51, D6S1043, D3S1358, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX, Penta E, TH01, D12S391, D2S1338, and FGA) and the risk genetic factors of substance use disorders(SUDs).Methods: The capillary electrophoresis was applied to analyze 19 STR loci in 156 drug abusers. The data of 6,134 healthy people in a previous study were applied to contrast as the control group. The differences in the frequency of the gene were analyzed by Chi-square test. Results: The gene distributions of 19 STR in drug addicts were consistent with hereditary rules. The frequency of vWA, FGA, Penta E was significantly different between the drug abuser and the control group (P<0.05).Conclusion: The 19 STR loci might provide highly informative polymorphic data for addicted genetic studies. Furthermore, there might be a predisposing gene for the drug abuser.

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“…We further conducted non-contributor tests [16] for each interpretation system. This was done by replacing the POI 10,000 times with a randomly generated profile ( H2 is true) from Philippine population allele frequencies [14]. LRmix Studio shows for each test the values for the minimum, maximum, as well as the 1st, 50th, and 99th percentiles among 10,000 LRs calculated, while STRmix™ reports all LR values.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems

et al. 2019

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In the paper, “Probabilistic approaches to interpreting two-person DNA mixtures from post-coital specimens” [1], we analysed 102 two-person DNA samples from simulated mixtures and male-female and male-male post-coital specimens. We report here data on profile characteristics of these samples and likelihood ratios (LRs) generated using semi- and fully continuous systems. Both log10 LRs from true and non-contributor tests are presented. These data may supplement studies comparing performance of different probabilistic systems for DNA evidence interpretation.

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Allele frequencies of 23 autosomal short tandem repeat loci in the Philippine population

Cited by 21 publications

References 7 publications

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

The Allele Frequency Variation of Autosomal 19 Short Tandem Repeat (STR) Loci in Drug Abuser: A Pilot Study

Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems

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Allele frequencies of 23 autosomal short tandem repeat loci in the Philippine population

Cited by 21 publications

References 7 publications

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

An integrated system for forensic DNA testing of sexual assault cases in the Philippines

The Allele Frequency Variation of Autosomal 19 Short Tandem Repeat (STR) Loci in Drug Abuser:&nbsp;A Pilot Study

Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems

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The Allele Frequency Variation of Autosomal 19 Short Tandem Repeat (STR) Loci in Drug Abuser: A Pilot Study