Allele frequencies and forensic parameters of 22 autosomal STR loci in a population of 983 individuals from Serbia and comparison with 24 other populations

DNA Paternıty Testıng wıth Two Mısmatches: Our Experıence

“…Considering all aforementioned, knowledge about mutation rates and possible mutational processes of different STR loci is important for accurate genetic profiles interpretation (Qian et al, 2015;Hamester et al, 2019). As previously mentioned in the Introduction section, a number of population-genetic studies, focused on evaluating of forensic efficiency parameters of STR markers (Grskovic et al, 2013 2016; Crnjac et al, 2017;Veselinovic et al, 2018;Al-Eitan et al, 2019;Al-Eitan et al, 2020;Pilav et al, 2020;Takic Miladinov et al, 2020) indicated a high degree of reliability of these markers important for all kinds of forensic-genetic analyses, including kinship and parentage testing. Finally, results from these two cases clearly demonstrate that X-STR markers have the potential to solve parentage cases not easily solved by standard analysis based on autosomal STR markers.…”

“…Besides high heterozygosity, discriminating power, clearly defined repetitive units and precisely determined allelic variants, simple amplification and detection of STR markers make them ideal for forensic analyses (Khalil et al, 2008;Primorac et al, 2014;Gomes et al, 2020). STR markers located on the autosomal, X and Y chromosomes are highly informative, practical and reliable for all kinds of forensic-genetic analyses including parentage testing, what was strongly supported by many population-genetic studies focused on investigating allele frequencies and forensic parameters (such as heterozygosity, power of discrimination, power of exclusion, polymorphic information content, matching probability and typical paternity index) of autosomal STR (Al-Eitan and Tubaishat, 2016;Al-Eitan et al, 2019;Al-Eitan et al, 2020;Pilav et al, 2020;Takic Miladinov et al, 2020) and X-STR loci (Grskovic et al, 2013;Crnjac et al, 2017;Veselinovic et al, 2018) in different populations. Generally, parentage testing follows Mendelian inheritance law, according to which child receives one allele from the mother and the other allele from the father .…”

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“…Considering all aforementioned, knowledge about mutation rates and possible mutational processes of different STR loci is important for accurate genetic profiles interpretation (Qian et al, 2015;Hamester et al, 2019). As previously mentioned in the Introduction section, a number of population-genetic studies, focused on evaluating of forensic efficiency parameters of STR markers (Grskovic et al, 2013 2016; Crnjac et al, 2017;Veselinovic et al, 2018;Al-Eitan et al, 2019;Al-Eitan et al, 2020;Pilav et al, 2020;Takic Miladinov et al, 2020) indicated a high degree of reliability of these markers important for all kinds of forensic-genetic analyses, including kinship and parentage testing. Finally, results from these two cases clearly demonstrate that X-STR markers have the potential to solve parentage cases not easily solved by standard analysis based on autosomal STR markers.…”

“…Besides high heterozygosity, discriminating power, clearly defined repetitive units and precisely determined allelic variants, simple amplification and detection of STR markers make them ideal for forensic analyses (Khalil et al, 2008;Primorac et al, 2014;Gomes et al, 2020). STR markers located on the autosomal, X and Y chromosomes are highly informative, practical and reliable for all kinds of forensic-genetic analyses including parentage testing, what was strongly supported by many population-genetic studies focused on investigating allele frequencies and forensic parameters (such as heterozygosity, power of discrimination, power of exclusion, polymorphic information content, matching probability and typical paternity index) of autosomal STR (Al-Eitan and Tubaishat, 2016;Al-Eitan et al, 2019;Al-Eitan et al, 2020;Pilav et al, 2020;Takic Miladinov et al, 2020) and X-STR loci (Grskovic et al, 2013;Crnjac et al, 2017;Veselinovic et al, 2018) in different populations. Generally, parentage testing follows Mendelian inheritance law, according to which child receives one allele from the mother and the other allele from the father .…”