All You Need To Know and More about the Diagnosis and Management of Rare Yeast Infections

Abstract

Invasive infections with emerging yeasts such as Geotrichum , Saprochaete/Magnusiomyces, Trichosporon , and other species are associated with high morbidity and mortality rates. Due to the rarity and heterogeneity of these yeasts, medical mycology has lacked guidance in critical areas affecting patient management.

Infección fúngica invasiva por Saprochaete capitata en un niño con aplasia medular

“…talidad y diferentes patrones de resistencia antifúngica según la especie (7) . En Perú son pocos los reportes realizados por infecciones fúngicas invasivas por hongos raros, tanto levaduriformes como filamentosos (8,9) .…”

“…S. capitata es un hongo raro levaduriforme que no ha sido previamente descrito en el Perú como causa de infección fúngica invasiva en humanos y que ha sido identificado, principalmente, en pacientes inmunocomprometidos, como se describe en el presente caso en un paciente con diagnóstico de aplasia medular y sometido a TPH. La epidemiología de las infecciones por S. capitata todavía no está bien establecida y la incidencia es baja, debido a las limitaciones existentes en los métodos de diagnóstico microbiológico y vigilancia epidemiológica, que también difieren entre países (1,7) . La mayoría de los casos y brotes nosocomiales han descrito principalmente en países de Europa (10) , mientras que, en Latinoamérica, Brasil ha reportado casos en pacientes con leucemia mieloide aguda (11,12) .…”

In vitro activity of manogepix and comparators against infrequently encountered yeast and mold isolates from the SENTRY Surveillance Program (2017–2022)

“…There are plenty of in vitro susceptibility data for common isolates of Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and C. krusei to the available systemically active antifungal agents, amphotericin B, fluconazole, voriconazole, and the echinocandins ( 6 ). The emerging, less common species of Candida often exhibit multidrug-resistant (MDR; resistant to at least one agent in two or more classes of antifungal agents) profiles (e.g., Candida auris, Candida guilliermondii, Candida rugosa, among others) and are a concern that underscores the need for accurate and timely species identification and antifungal susceptibility testing ( 7 – 11 ).…”

Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii

“…Common invasive fungal infections of COVID-19 patients are caused by Aspergillus spp., Candida spp., and Mucormycetes ( 1 ). It is noteworthy that recent investigations discovered that hospitalized COVID-19 patients had a high risk of developing invasive trichosporonosis, a rare yeast infection mainly caused by Trichosporon asahii ( 2 , 3 ). Systemic infection with this emergent yeast is most often fatal.…”