All-trans Retinoic Acid Is Increased in the Acute Phase-Related Hyporetinemia During Escherichia coli Mastitis

Merris, Van; Meyer, Evelyne; Duchateau, Luc; Blum, Jürg W.; Burvenich, Christian

doi:10.3168/jds.s0022-0302(04)73243-9

Cited by 20 publications

(20 citation statements)

References 31 publications

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“…Serum concentrations of all-trans-and 13-cis-retinoic acid remain stable around parturition in dairy cows (Goff et al, 2002) but are affected by the acute-phase reaction during E. coli mastitis (Van Merris et al, 2004). During acute coliform mastitis, an increase of all-trans-retinoic acid is mirrored by decreased 13-cisretinoic acid concentrations, suggesting that a transient bio-activation occurs in the retinoid metabolism.…”

Section: Discussionmentioning

confidence: 88%

“…We hypothesize that an important role can be attributed to retinoic acid in the regulation of bovine myelopoiesis because we previously demonstrated a shift in retinoid metabolism to occur during acute E. coli mastitis (Van Merris et al, 2004). During the acute-phase reaction, metabolism preferentially results in the production of all-trans-retinoic acid.…”

Section: Discussionmentioning

confidence: 99%

“…We recently observed a shift in retinoid metabolism during experimentally induced E. coli mastitis in the immediate postpartum period, suggesting a key role for the biologically active metabolite all-trans-retinoic acid (Van Merris et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Differential Effects of Steroids and Retinoids on Bovine Myelopoiesis in Vitro

Merris

Meyer

Duchateau

et al. 2004

Journal of Dairy Science

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Pregnancy and parturition are associated with physiological changes caused by steroid hormones. Alterations in number, maturity, and function of polymorphonuclear leukocytes observed in dairy cows at parturition suggest a common causative relationship with steroid hormones. This study was designed to investigate the effects of progesterone, 17-β-estradiol, and hydrocortisone on the proliferation of bovine progenitor cells. An in vitro culturing system was used, and colonies were scored after 7 d of incubation. At low concentrations, 17-β-estradiol inhibited proliferation of granulocyte progenitor cells. Hydrocortisone reduced growth of granulocyte and monocyte colonies, whereas myelopoiesis was not altered by progesterone. Furthermore, we studied the effect of retinoids on colony formation of bovine bone marrow cells. All-trans-and 9-cis-retinoic acid stimulated growth of granulocyte colonies and inhibited proliferation of the monocyte lineage. The addition of the 13-cis-isomer also increased numbers of granulocyte colony-forming units. This study indicates that steroid hormones may be responsible for alterations in the bovine hematopoietic profiles observed in circulation during the postpartum period. White blood cells, especially polymorphonuclear leukocytes, which are derived from bone marrow, are an important first line defense against mastitis. Therefore, these effects of steroids might contribute to the increased susceptibility of dairy cows to Escherichia coli mastitis. We furthermore hypothesize that an important role might be attributed to retinoic acid in its regulation of bovine myelopoiesis. Modulation of myelopoiesis in favor of the granulocyte lineage during the acute-phase reaction may be an adaptive mechanism designed to increase the capacity of first-line defense to intramammary infections. Received: October 8, 2003. Accepted: November 6, 2003 Corresponding author: C. Burvenich; e-mail: Christian.Burvenich @UGent.be. 1188(Key words: steroid hormone, retinoic acid, bone marrow, myelopoiesis) Abbreviation key: cfu-G = colony-forming unit-granulocyte, cfu-GM = colony-forming unit-granulocyte and monocyte, cfu-M = colony-forming unit-monocyte, cfutotal = colony-forming unit-total myeloid, FBS = fetal bovine serum, IMDM = Iscove's modified Dulbecco's Minimal Essential, PMN = polymorphonuclear leukocytes, RAR = retinoic acid receptor, RXR = retinoid X receptor.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Differential Effects of Steroids and Retinoids on Bovine Myelopoiesis in Vitro

Merris

Meyer

Duchateau

et al. 2004

Journal of Dairy Science

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“…Reverse phase-high performance liquid chromatography (HPLC) Cells were quantified and extracted as described previously (Van Merris et al, 2004). Reverse-phase HPLC (RP-HPLC) was carried out on an AKTA Explorer HPLC system (GE Healthcare Life Sciences, UK).…”

Section: Oil Red O Stainingmentioning

confidence: 99%

Retinol Binding Protein-Albumin Domain III Fusion Protein Deactivates Hepatic Stellate Cells

Park

Choi

Lee

et al. 2012

Molecules and Cells

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Liver fibrosis is characterized by accumulation of extracellular matrix, and activated hepatic stellate cells (HSCs) are the primary source of the fibrotic neomatrix and considered as therapeutic target cells. We previously showed that albumin in pancreatic stellate cells (PSCs), the key cell type for pancreatic fibrogenesis, is directly involved in the formation of vitamin A-containing lipid droplets, inhibiting PSC activation. In this study, we evaluated the anti-fibrotic activity of both albumin and retinol binding protein-albumin domain III fusion protein (R-III), designed for stellate cell-targeted delivery of albumin III, in rat primary HSCs and investigated the underlying mechanism. Forced expression of albumin or R-III in HSCs after passage 2 (activated HSCs) induced lipid droplet formation and deactivated HSCs, whereas point mutations in high-affinity fatty acid binding sites of albumin domain III abolished their activities. Exogenous R-III, but not albumin, was successfully internalized into and deactivated HSC-P2. When HSCs at day 3 after plating (pre-activated HSCs) were cultured in the presence of purified R-III, spontaneous activation of HSCs was inhibited even after passage 2, suggestive of a potential for preventive effect. Furthermore, treatment of HSCs-P2 with R-III led to a significant reduction in both cytoplasmic levels of all-trans retinoic acid and the subsequent retinoic acid signaling. Therefore, our data suggest that albumin deactivates HSCs with reduced retinoic acid levels and that R-III may have therapeutic and preventive potentials on liver fibrosis.

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“…Retinol represents the most abundant retinoid in bovine blood (Van Merris et al 2004) and its levels in steers are maintained for at least 145 d even if the animals are fed a diet with no supplemental vitamin A (Gorocica-Buenfil et al 2008). However, plasma retinol and b-carotene levels in heifers and cows decrease at the end of gestation, reach their lowest values around parturition and increase again during the first week of lactation (Johnston & Chew, 1984;Goff & Stabel, 1990 ;Lindberg et al 1999;Kumagai et al 2000;Kumagai et al 2001 ;Nonnecke et al 2001 ;Goff et al 2002 ;Van Merris et al 2004 ;Debier et al 2005;Rezamand et al 2007).…”

mentioning

confidence: 99%

Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period

Eldaim

Kamikawa

Soliman

et al. 2009

Journal of Dairy Research

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Retinol-binding protein 4 (RBP4) is a plasma protein involved in retinol transportation, and recent evidence in rodents suggests that RBP4 is also a metabolic regulator that modifies insulin sensitivity. To assess how RBP4 levels are regulated in ruminants, we determined the RBP4 concentrations in bovine plasma and milk using Western blot analysis. Plasma RBP4 levels in non-pregnant non-lactating (control) cows were around 45 mg/ml, which were sustained during 60-h fasting, but decreased significantly 4 h after lipopolysaccharide (LPS) administration. Basal plasma retinol concentration was around 30 mg/dl, but this decreased to approximately one-third and one-half of these values during fasting and 8 h after LPS challenge, respectively. Plasma RBP4 and retinol levels in cows 3-6 d before parturition were comparable to those of the controls. However, on the day of parturition both were significantly decreased and had returned to basal levels by two weeks after calving. Interestingly, RBP4 was clearly detected in colostrum (16 . 4±5 . 6 mg/ml) but was only faintly detected in milk from cows at 7 d and 15 d after calving. Retinol concentrations in colostrum were almost 10-fold higher than those in plasma, while those in milk were comparable to those in plasma. These results suggest that RBP4 and retinol levels are independently regulated under physiological and pathophysiological conditions and that RBP4, like retinol, is transferred from maternal stores to calves through colostrum.

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All-trans Retinoic Acid Is Increased in the Acute Phase-Related Hyporetinemia During Escherichia coli Mastitis

Cited by 20 publications

References 31 publications

Differential Effects of Steroids and Retinoids on Bovine Myelopoiesis in Vitro

Differential Effects of Steroids and Retinoids on Bovine Myelopoiesis in Vitro

Retinol Binding Protein-Albumin Domain III Fusion Protein Deactivates Hepatic Stellate Cells

Retinol binding protein 4 in dairy cows: its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period

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