“…FABP4, also called the adipose FABP (A-FABP) or aP2, is one of the most studied FABPs and several small-molecule FABP4 inhibitors have emerged. The binding affinity and specificity between FABP4 and natural ligands is mainly achieved by hydrogen bonding between the carboxylic end of fatty acids and Arg106 (via a water molecule), Arg126, and Tyr128. , Based on their chemical structures, FABP4 inhibitors can be classified into pyrazole, oxazole, imidazole, triazole, indole, benzimidazole, thiophene and thiazoles, pyrimidine, bicyclic pyridine and quinoxaline, urea and carbamoyl, sulfonamide, 2-aminobenzoic acid, and other compounds. , …”