All-optical phase modulation for integrated interferometric biosensors

Dante, Stefania; Duval, Daphné; Sepúlveda, Borja; González-Guerrero, Ana Belén; Sendra, José Ramón Sendra; Lechuga, Laura M.

doi:10.1364/oe.20.007195

Cited by 88 publications

(51 citation statements)

References 22 publications

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“…A refractometric detection limit of 10 −8 RIU can be achieved [245,246] with interferometers, which is lower than so far possible experimentally for WGM-type devices. The concentration detection limits on the order of ng/mL or less [247].…”

Section: Optical Methodsmentioning

confidence: 79%

Whispering Gallery Mode Devices for Sensing and Biosensing

François¹,

Zhi

Meldrum

2015

Photonic Materials for Sensing, Biosensing and Display Devices

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Optical sensors based on resonant whispering gallery mode (WGM) optical cavities are discussed in the context of recent research developments. WGM-based sensors are among the most sensitive optical sensing devices currently known, especially when combined with surface plasmon effects. The basic theory of WGM "reactive" sensing is first discussed, along with the basic parameters that are used to characterize such devices (i.e., sensitivity, signal-to-noise ratio, and detection limit). Surface chemistry methods are of critical importance for targeted sensing applications and the fundamentals of this aspect are examined. The performance of fluorescent WGM-based devices is compared to state-of-the-art "evanescently-coupled" structures. Finally, the performance of WGM-based optical sensors is compared and contrasted to a range of alternative optical microsensor technologies currently under development.A. François

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Section: Optical Methodsmentioning

confidence: 79%

Whispering Gallery Mode Devices for Sensing and Biosensing

François¹,

Zhi

Meldrum

2015

Photonic Materials for Sensing, Biosensing and Display Devices

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“…By mixing the output signal of the MZI with the proper multiple of ω 0 and applying a low-pass filter to the signals to remove the frequencies above the band of interest, it is possible to obtain signals that are proportional to sin Δφ(t) and cos Δφ(t), from which the phase can be extracted by using the arc-tangent demodulation technique [13].…”

Section: Theorymentioning

confidence: 99%

“…The condition J 1 (C) = J 2 (C) can be satisfied when the modulation amplitude is C=0.84π [13], then the phase variation can be obtained from:…”

Section: Theorymentioning

confidence: 99%

Integrated FBG sensors interrogator in silicon photonic platform using active interferometer monitoring

et al. 2016

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We experimentally demonstrate the feasibility of Fiber Bragg Grating sensors interrogation using integrated unbalanced Mach-Zehnder Interferometers (MZI) and phase sensitive detection in silicon-on-insulator (SOI) platform. The Phase- Generated Carrier (PGC) demodulation technique is used to detect phase changes, avoiding signal fading. Signal processing allows us to extract the wavelength shift from the signal patterns, allowing accurate dynamic FBG interrogation. High resolution and low cost chips with multiple interrogators and photodetectors on board can be realized by exploiting the advantages of large scale fabrication capabilities of well-established silicon based industrial infrastructures. Simultaneous dynamic reading of a large number of FBG sensors can lead to large volume market applications of the technology in several strategic industrial fields. The performance of the proposed integrated FBG interrogator is validated by comparing with a commercial FBG readout based on a spectrometer and used as a reference

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“…An even simpler approach to overcome MZI drawbacks and ambiguities is proposed by Dante et al 8 . In this proposal the sensor phase is tuned by modulating the laser emission wavelength periodically.…”

Section: Mzi Enhancements To Circumvent Ambiguitiesmentioning

confidence: 99%

Migrating the Mach-Zehnder chemical and bio-sensor to the mid-infrared region

Leidner

Ewald

Sieger

et al. 2013

Optical Sensors 2013

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The properties of integrated optical phase-modulated Mach-Zehnder interferometers (IO-MZI) are used to set up a new generation of chemical and biochemical sensors working in the mid-infrared. First applications of the MZI principle were introduced in the beginning 1990s. They range from a gas sensor to monitor organic solvent concentrations 1 to setting up an immunoassay for the detection of the herbicide simazine 2 . Most if not all sensors of MZI type operate at wavelengths of the visible or near infrared spectrum. There are several reasons to change this strategy and move into the mid-infrared spectral range (MIR): higher manufacturing tolerances, increased evanescent field penetration depth, signal amplification by surface enhanced infrared absorption effect (SEIRA), species identification by MIR fingerprints.The basis of the planned MIR-MZI is a GaAs waveguide pattern epitaxially grown on a substrate 3 . As a first step towards nanostructuring the waveguide surface, chemical deposition of Au nanoparticles on GaAs transducers was established. For the use of MIR-MZI sensors in bioanalytical assay development, chemical immobilization of molecular recognition elements on GaAs transducers was carried out. The modified surfaces were characterized by atomic force microscopy (AFM), dark field microscopy, contact angle measurements and ellipsometric data as well as by a modified version of Reflectometric Interference Spectroscopy (RIfS) 4 . It was possible to monitor both the immobilization of gold nanoparticles and time-resolved specific binding using a model antibody antigen assay.After successful setup of relevant assays with RIfS, e.g. the detection of bacteria or endocrine disruptors, the assays are designed to be transferred onto the mid-infrared Mach-Zehnder interferometer.

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All-optical phase modulation for integrated interferometric biosensors

Cited by 88 publications

References 22 publications

Whispering Gallery Mode Devices for Sensing and Biosensing

Whispering Gallery Mode Devices for Sensing and Biosensing

Integrated FBG sensors interrogator in silicon photonic platform using active interferometer monitoring

Migrating the Mach-Zehnder chemical and bio-sensor to the mid-infrared region

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