Optical Kerr signals from GaAs/AlAs multilayer micro‐cavities with GaAs/AlGaAs multi‐quantum wells (MQW) in the half‐wavelength cavity layer were investigated. The cavity‐mode‐wavelengths were set at the resonance region of two‐photon absorption of the MQWs in the 1.5‐μm band. The measured intensities of the signals depended strongly on the cavity‐mode wavelength, although the cavity layers including the MQW and multilayers maintained approximately the same structure. The nonlinearity of the MQW is considered to vary considerably at the resonant wavelength of the two‐photon absorption. The results indicate that the optical Kerr signal of the multilayer micro‐cavity is dominated by the nonlinearity of the cavity layer, although the cavity layer is only a small part of the total cavity thickness. This experimentally confirms the results of a previous simulation study on the multilayer cavities. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)