All-night functional magnetic resonance imaging sleep studies

Moehlman, Thomas M.; Zwart, Jacco A. de; Chappel‐Farley, Miranda G.; Liu, Xiao; McClain, Irene B.; Chang, Catie; Mandelkow, Hendrik; Özbay, Pinar Senay; Johnson, Nicholas L.; Bieber, Rebecca E.; Fernandez, Katharine A.; King, Kelly A.; Zalewski, Christopher; Brewer, Carmen C.; Gelderen, Peter van; Duyn, Jeff H.; Picchioni, Dante

doi:10.1016/j.jneumeth.2018.09.019

Cited by 24 publications

(23 citation statements)

References 85 publications

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“…To increase the within-subject data to improve reliability, a longer recording time is needed. A full-night scanning pulse sequence can be helpful for future studies (Moehlman et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…We could restart another EEG‐fMRI scan, but the obvious changes in scanner noise during the switch between fMRI scans would have aroused the subjects and affected the sleep structure. However, in future studies, this problem can be solved by modifying the pulse sequence to overcome limits related to scanning volume in a session (Moehlman et al, 2019). With this advantage, data on REM stage can also be recorded, and the brain mechanisms of insomnia disorder can be more comprehensively understood.…”

Section: Discussionmentioning

confidence: 99%

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Altered thalamic connectivity in insomnia disorder during wakefulness and sleep

Zou

Liu

et al. 2020

Human Brain Mapping

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Insomnia disorder is the most common sleep disorder and has drawn increasing attention. Many studies have shown that hyperarousal plays a key role in the pathophysiology of insomnia disorder. However, the specific brain mechanisms underlying insomnia disorder remain unclear. To elucidate the neuropathophysiology of insomnia disorder, we investigated the brain functional networks of patients with insomnia disorder and healthy controls across the sleep-wake cycle. EEG-fMRI data from 33 patients with insomnia disorder and 31 well-matched healthy controls during wakefulness and nonrapid eye movement sleep, including N1, N2 and N3 stages, were analyzed. A medial and anterior thalamic region was selected as the seed considering its role in sleep-wake regulation. The functional connectivity between the thalamic seed and voxels across the brain was calculated. ANOVA with factors "group" and "stage" was performed on thalamus-based functional connectivity. Correlations between the misperception index and altered functional connectivity were explored. A group-by-stage interaction was observed at widespread cortical regions. Regarding the main effect of group, patients with insomnia disorder demonstrated decreased thalamic connectivity with the left amygdala, parahippocampal gyrus, putamen, pallidum and hippocampus across wakefulness and all three nonrapid eye movement sleep stages. The thalamic connectivity in the subcortical cluster and the right Guangyuan Zou and Yuezhen Li contributed equally to this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered thalamic connectivity in insomnia disorder during wakefulness and sleep

Zou

Liu

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Because hemodynamic activities have slower response time than neural activities, fMRI cannot detect neural oscillation beyond the frequency of hemodynamic responses [ 11 ]. Given the constraints of individual brain imaging techniques, a number of studies have applied a multimodal imaging approach, such as combined EEG-fMRI, to simultaneously track global brain state and record local brain activity during human sleep [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping brain

Song

Tagliazucchi

2020

Current Opinion in Physiology

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Sleep and wakefulness are traditionally considered as two mutually exclusive states with contrasting behavioural manifestations and complementary neurobiological functions. However, the discoveries of local sleep in global wakefulness and local wakefulness in global sleep have challenged this classical view and raised questions about the nature and functions of sleep. Here, we review the contributions from recent multimodal imaging studies of human sleep towards understanding the relationship between the nature and functions of sleep. Through simultaneous tracking of brain state and mapping of brain activity, these studies revealed that the sleeping brain can carry out covert cognitive processing that was thought to be wake-specific (wake-like function in the sleeping brain). Conversely, the awake brain can perform housekeeping functions through local sleep of neural populations (sleep-like function in the awake brain). We discuss how the blurred boundary between sleep and wakefulness highlights the need to radically rethink the definition of brain states, and how the recently discovered fMRI signatures of global and local sleep can help to address these outstanding questions.

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“…Manifestations of DOAs were also examined by fMRI [ 11 ] and the positron emission tomography [ 12 ]. Simultaneous sleep recordings using EEG and fMRI have been described in studies [ 13 , 14 , 15 , 16 , 17 ], but without specifically focusing on parasomnia. Sleep is usually studied by well established EEG components which are, however, originated in deep brain sources.…”

Section: Introductionmentioning

confidence: 99%

“…Hong et al recorded simultaneous EEG and fMRI throughout the entire night, but the recordings were discontinuous [ 20 ]. Moehlman et al continuously recorded EEG and fMRI sleep data throughout the entire night [ 16 ]; however, how the continuous recording was achieved was not specified in detail.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous fMRI-EEG-Based Characterisation of NREM Parasomnia Disease: Methods and Limitations

et al. 2020

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Functional magnetic resonance imaging (fMRI) techniques and electroencephalography (EEG) were used to investigate sleep with a focus on impaired arousal mechanisms in disorders of arousal (DOAs). With a prevalence of 2–4% in adults, DOAs are significant disorders that are currently gaining attention among physicians. The paper describes a simultaneous EEG and fMRI experiment conducted in adult individuals with DOAs (n=10). Both EEG and fMRI data were validated by reproducing well established EEG and fMRI associations. A method for identification of both brain functional areas and EEG rhythms associated with DOAs in shallow sleep was designed. Significant differences between patients and controls were found in delta, theta, and alpha bands during awakening epochs. General linear models of the blood-oxygen-level-dependent signal have shown the secondary visual cortex and dorsal posterior cingulate cortex to be associated with alpha spectral power fluctuations, and the precuneus with delta spectral power fluctuations, specifically in patients and not in controls. Future EEG–fMRI sleep studies should also consider subject comfort as an important aspect in the experimental design.

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All-night functional magnetic resonance imaging sleep studies

Cited by 24 publications

References 85 publications

Altered thalamic connectivity in insomnia disorder during wakefulness and sleep

Altered thalamic connectivity in insomnia disorder during wakefulness and sleep

Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping brain

Simultaneous fMRI-EEG-Based Characterisation of NREM Parasomnia Disease: Methods and Limitations

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