All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans

Zand, Janet; Lanza, Frank L.; Garg, Harsha K.; Bryan, Nathan S.

doi:10.1016/j.nutres.2011.03.008

Cited by 90 publications

(74 citation statements)

References 39 publications

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“…Studies also emphases that lower NO production causes hyperlipidemia (Zand et al, 2011;Ma et al, 2011;Goto et al 1999). Hyperlipidemia is one of the metabolic complications of both clinical and experimental diabetes.…”

Section: Introductionmentioning

confidence: 99%

The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats

Akyüz¹,

Tekin²,

Aydn³

et al. 2012

Afr. J. Pharm. Pharmacol.

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The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. Male wistar rats were used to conduct the study and they were divided into five groups of 8 rats in each. These groups are: Control group, diabetes group (STZ-NA), diabetes and metformin (DMet) group, diabetes and exercise (DE) group, and diabetes + exercise + metformin (DEMet) group. The STZ-NA induced diabetic rats were used as a model of type 2 diabetes. Metformin was orally administered to rats. For exercise intervention, rats were forced to run in a running wheel for 10 min each day (20 m/min/day). At the end of experimental period, blood glucose, glycated hemoglobin (HbA1c) levels, plasma lecithin:cholesterol acyltransferase (LCAT) levels, serum triglyceride (TG), cholesterol, high density lipoprotein (HDL), Apo A-I, NOS and liver NO levels were determined. Metformin caused beneficial changes in blood glucose, HbA1c levels, and HDL in type 2 diabetic rats. Both administration of metformin and exercise intervention independently caused beneficial changes in blood glucose. However, the surprising result found was that exercise intervention did not optimize the result of metformin treatment. The other finding of this study was that exercise intervention increased cholesterol and NOS level but exercise combined with metformin was not better than exercise alone. Thus, it appears from the present study that metformin and exercise combination has no effect.

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Section: Introductionmentioning

confidence: 99%

The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats

Akyüz¹,

Tekin²,

Aydn³

et al. 2012

Afr. J. Pharm. Pharmacol.

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“…Replenishing nitrite through dietary means may then act as a protective measure to compensate for insufficient NOS activity under conditions of hypoxia or in a number of conditions characterized by NO insufficiency. Studies using a patented formulation (US patents 8,303,995,8,298,589,8,435,5708 8,962,038 9,119,823 & 9,241,999 ) in the form of an orally disintegrating tablet found that it could modify cardiovascular risk factors in patients over the age of 40, significantly reduce triglycerides, and reduce blood pressure [59]. This same lozenge was used in a pediatric patient with argininosuccinic aciduria and significantly reduced his blood pressure when prescription medications were ineffective [76].…”

Section: Resultsmentioning

confidence: 99%

“…Most recently, a dietary supplement formulated with dietary nitrite and natural product chemistry to reduce nitrite to NO has been shown to modify cardiovascular risk in patients over the age of 40, reduce blood pressure and reduce markers of inflammation [59]. All of these studies, alongside the observation that nitrite can act as a marker of NOS activity [31] opened a new avenue for the diagnostic and therapeutic application of nitrite, especially in cardiovascular diseases, using nitrite as marker as well as an active agent.…”

Section: Figurementioning

confidence: 99%

Dietary Nitrite: from menace to marvel

Bryan¹

2016

FFHD

Self Cite

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ABSTRACT:The health benefits of nitrite are now indisputable when administered in a clinical setting for specific diseases. Currently, most published reports identify the production of nitric oxide (NO) as the mechanism of action for nitrite. Basic science, in addition to clinical studies, demonstrate that nitrite and/or nitrate cannot restore NO homeostasis as an endothelium independent source of NO that may be a redundant system for endogenous NO production. Nitrate must first be reduced to nitrite by oral commensal bacteria; nitrite can then be further reduced to NO along the physiological oxygen gradient. But despite decades of rigorous research on sodium nitrate's safety and efficacy as a curing agent, sodium nitrite is still regarded by many as a toxic undesirable food additive. However, research within the biomedical science community has revealed enormous therapeutic benefits of nitrite which are being developed as novel therapies for conditions associated with nitric oxide insufficiency. Thus, this review will highlight the fundamental biochemistry of nitrite in human physiology and provide evidence that nitrite be considered an essential nutrient. Foods or diets enriched with nitrite can have profound positive health benefits.

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“…More recent research has shown that C57BL6 mice fed a high fat diet but supplemented with NO 2 − -containing drinking water for 3 weeks exhibited reduced leukocyte adhesion and arteriolar endothelial dysfunction together with a reduced triglyceride level compared to those fed NO 2 − -free water [123]. Interestingly, in a small study in patients with hypercholesterolemia, a significant reduction in triglyceride levels following dietary NO 2 − has been reported [124]. In this study 23 hypercholesterolemic patients were given a commercially available supplement containing a number of different herbal constituents proposed to enhance NO 3 − and NO 2 − delivery in vivo.…”

Section: Nomentioning

confidence: 99%

A ‘green’ diet‐based approach to cardiovascular health? Is inorganic nitrate the answer?

Rathod

Velmurugan

Ahluwalia

2015

Molecular Nutrition Food Res

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Ingestion of fruit and vegetables rich in inorganic nitrate (NO(3)(-)) has emerged as an effective method for acutely elevating vascular nitric oxide (NO) levels through formation of an NO(2)(-) intermediate. As such a number of beneficial effects of NO(3)(-) and NO(2)(-) ingestion have been demonstrated including reductions in blood pressure, measures of arterial stiffness and platelet activity. The pathway for NO generation from such dietary interventions involves the activity of facultative oral microflora that facilitate the reduction of inorganic NO(3)(-), ingested in the diet, to inorganic NO(2)(-). This NO(2)(-) then eventually enters the circulation where, through the activity of one or more of a range of distinct NO(2)(-) reductases, it is chemically reduced to NO. This pathway provides an alternative route for in vivo NO generation that could be utilized for therapeutic benefit in those cardiovascular disease states where reduced bioavailable NO is thought to contribute to pathogenesis. Indeed, the cardiovascular benefits of NO(2)(-) and NO(3)(-) are now starting to be translated in patients in several clinical trials. In this review, we discuss recent evidence supporting the potential utility of delivery of NO(3)(-) or NO(2)(-) for the treatment of cardiovascular diseases.

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All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans

Cited by 90 publications

References 39 publications

The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats

The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats

Dietary Nitrite: from menace to marvel

A ‘green’ diet‐based approach to cardiovascular health? Is inorganic nitrate the answer?

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