All-lignin approach to prepare cationic colloidal lignin particles: stabilization of durable Pickering emulsions

Sipponen, Mika H.; Smyth, Matthew; Leskinen, Timo; Johansson, Leena‐Sisko; Österberg, Monika

doi:10.1039/c7gc02900d

Cited by 147 publications

(174 citation statements)

References 40 publications

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“…The most common method for the preparation of LNPs involves solvent exchange by adding a non‐solvent into lignin solution, or vice versa, causing formation of spherical particles due to the minimization of surface energy (Figure a–c) . Aqueous and non‐aqueous solvents (THF, dioxane, dimethyl sulfoxide, acetone, and ethanol) have been used to dissolve lignin, with water being the most commonly used non‐solvent to produce spherical particles. In the case of ethanol–water solvent mixture, the particle diameter has been reported to controllably increase as the dilution rate decreases (Figure c) .…”

Section: Lignin‐based Materials and Methods For Active‐substance Loadingmentioning

confidence: 99%

“… with permission from The Royal Society of Chemistry); (c) nanoprecipitation by adding water to a lignin solution, or vice versa. Common solvents used include ethanol, THF, and acetone . (d) Formation of micro‐ and nanoparticles in an aerosol flow reactor (adapted with permission from Ref.…”

Section: Lignin‐based Materials and Methods For Active‐substance Loadingmentioning

confidence: 99%

“…Activation of lipases occurs because of the amphiphilic properties of lignins, which are similar to those of synthetic surfactants . Lipase from Aspergillus niger was adsorbed on a composite material consisting of chitin and oxidized KL .…”

Section: Entrapment Encapsulation and Adsorption Of Active Substancmentioning

confidence: 99%

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Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

et al. 2019

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To liberate society from its dependence on fossil‐based fuels and materials it is pivotal to explore components of renewable plant biomass in applications that benefit from their intrinsic biodegradability, safety, and sustainability. Lignin, a byproduct of the pulp and paper industry, is a plausible material for carrying various types of cargo in small‐ and large‐scale applications. Herein, possibilities and constraints regarding the physical–chemical properties of the lignin source as well as modifications and processing required to render lignins suitable for the loading and release of pesticides, pharmaceuticals, and biological macromolecules is reviewed. In addition, the technical challenges, regulatory and toxicological aspects, and future research needed to realize some of the promises that nano‐ and microscaled lignin materials hold for a sustainable future are critically discussed.

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Section: Lignin‐based Materials and Methods For Active‐substance Loadingmentioning

confidence: 99%

Section: Lignin‐based Materials and Methods For Active‐substance Loadingmentioning

confidence: 99%

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Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

et al. 2019

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“…129,130 Fully bio-based Kraft lignin nanoparticles were surface-treated by adsorbing cationic lignin, to extend the emulsion stabilization array. 131 Kraft lignin nanoparticles were also coated with chitosan, used as emulsifiers, and further crosslinked with sodium triphosphate to achieve a strong stability against emulsion coalescence. 132 Recent efforts in lignin nanoparticle research tackle the challenge of their continuous production by using a microchannel 126 and a potentially scalable preparation by spray-freezing.…”

Section: Regenerated Cellulosementioning

confidence: 99%

Strategies for structuring diverse emulsion systems by using wood lignocellulose-derived stabilizers

Mikkonen

2020

Green Chem.

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Wood biomass is an abundant renewable source of materials, but due to the accelerating depletion of natural resources, it is important to explore new ways to use it in a more sustainable manner. Modern technologies enable the recovery and valorization of the main components of wood-namely, cellulose, lignin, and hemicelluloses-contributing to sustainability. However, the method of isolation and resulting structure and purity of lignocellulosic materials determine their functionality and applicability. This review discusses the properties of all three main wood-based compounds that can stabilize emulsions, a class of industrial dispersions that are widely used in life science applications and chemicals. Due to the multibillion-dollar annual market for hydrocolloids, the food, pharmaceutical, cosmetic, coating, and paint industries are actively seeking new sustainable emulsion stabilizers that fulfill the demanding requirements regarding safety and functionality. Wood-derived stabilizers facilitate various mechanisms involved in emulsion stabilization: (1) development of amphiphilic structures that decrease interfacial tension, (2) stabilization of interfaces by particles according to the Pickering theory, and (3) increase in the viscosity of emulsions' continuous phase. This review presents pathways for treating cellulose, lignin, and hemicelluloses to achieve efficient stabilization and provides suggestions for their broad use in emulsions.

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“…Additionally, aliphatic hydroxyl, phenolic hydroxyl, and carboxyl groups of original softwood kraft lignin and carboxylated lignins were analyzed by quantitative 31 P NMR spectroscopy . The sample preparation and analysis was carried out as described earlier, except that now the sample weight was 25 mg and 15 relaxation time was used in the inverse‐gated pulse sequence …”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of Dentin Phosphophoryn‐Derived Peptide‐Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake

Figueiredo

Sipponen

Lintinen

et al. 2019

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The surface modification of nanoparticles (NPs) using different ligands is a common strategy to increase NP−cell interactions. Here, dentin phosphophoryn‐derived peptide (DSS) lignin nanoparticles (LNPs) are prepared and characterized, the cellular internalization of the DSS‐functionalized LNPs (LNPs‐DSS) into three different cancer cell lines is evaluated, and their efficacy with the widely used iRGD peptide is compared. It is shown that controlled extent of carboxylation of lignin improves the stability at physiological conditions of LNPs formed upon solvent exchange. Functionalization with DSS and iRGD peptides maintains the spherical morphology and moderate polydispersity of LNPs. The LNPs exhibit good cytocompatibility when cultured with PC3‐MM2, MDA‐MB‐231, and A549 in the conventional 2D model and in the 3D cell spheroid morphology. Importantly, the 3D cell models reveal augmented internalization of peptide‐functionalized LNPs and improve antiproliferative effects when the LNPs are loaded with a cytotoxic compound. Overall, LNPs‐DSS show equal or even superior cellular internalization than the LNPs‐iRGD, suggesting that DSS can also be used to enhance the cellular uptake of NPs into different types of cells, and release different cargos intracellularly.

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All-lignin approach to prepare cationic colloidal lignin particles: stabilization of durable Pickering emulsions

Abstract: Adsorption of cationic lignin on colloidal lignin particles is a green route to new types of Pickering emulsion applications.

Cited by 147 publications

References 40 publications

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

Strategies for structuring diverse emulsion systems by using wood lignocellulose-derived stabilizers

Preparation and Characterization of Dentin Phosphophoryn‐Derived Peptide‐Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake

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