“All‐in‐One” Nanoparticles for Trimodality Imaging‐Guided Intracellular Photo‐magnetic Hyperthermia Therapy under Intravenous Administration

H, Yan; Shang, Wenting; Sun, Xiaodan; Zhao, Lingyun; Wang, Jingyun; Xiong, Zhiyuan; Yuan, Jie; Zhang, Ranran; Huang, Qianli; Wang, Kun; Li, Baohua; Tian, Jie; Kang, Feiyu; Feng, Si‐Shen

doi:10.1002/adfm.201705710

Cited by 95 publications

(57 citation statements)

References 39 publications

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“…A variety of devices comprising magnetic nanoparticles capped with photoresponsive polymers to more complex magnetic mesoporous silica nanoparticles capped with graphene quantum dots have been recently described. Thus, this approximation has proved its potential by combining MH, phototermal therapy (PTT), chemotherapy, and even imaging in vitro and in vivo, which makes them excellent candidates for multimodal treatment of cancer …”

Section: Bonus Track: Co‐working Between Photo‐ and Magnetic Heating:mentioning

confidence: 99%

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

et al. 2018

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that cancer cells are more sensitive to heat than normal ones [2,3] and the huge advances in the field of nanotechnology have given researchers new tools to design new, more sophisticated, and more specific heat treatments. Here, we focus on several electromagnetic responsive nanomaterials capable of acting as thermoseeds, which can induce changes in their environment through heating processes. We will pay special attention to the heat generation and its applications, as well as the biological response to the temperature rise at the nanoscale. Two sorts of nanomaterials that allow these new thermaltreatment approaches are especially attractive, depending on the radiation used to provoke the nanomaterial's response. Answering to the type of radiation used to carry out hyperthermia treatments, the nanomaterial characteristics required are completely different. The first application is typically called magnetic hyperthermia (MH), which uses alternating magnetic fields (AMFs); which are electromagnetic (EM) waves in the range of the EM spectrum that corresponds to radiofrequency (RF). The second, typically called optical hyperthermia, uses radiation in the part of the EM spectrum that corresponds to the near-infrared (NIR).The first approaches in hyperthermia treatments in both optical and magnetic stimuli mediated by nanoparticles were focused on the idea of using high doses of nanomaterials to produce enough heat to kill cancer cells by a global temperature increase. Researchers working in this field have to face several drawbacks, as the difficulty of localizing a high concentration of material in the target tissue, inadequate animal models, inaccurate temperature measurement, or limitations of the source conditions that can be used for in vivo experiments make the temperature rise often insufficient. [4] First, it is important to consider that the half-life and tissue penetration of the nanocarrier does not depend on the nanoparticle nature but on the coatings developed to enhance their stability in the physiological environment. Therefore, besides the heating efficiency, the predominant factor in the choice of hyperthermia generation is restricted by the location of the cancer tissue. Both RF and NIR irradiation can be considered useful external and noninvasive stimuli, but the main difference between the two is the tissue penetration. While magnetic fields Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic-and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscal...

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Section: Bonus Track: Co‐working Between Photo‐ and Magnetic Heating:mentioning

confidence: 99%

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

et al. 2018

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“…Advances in nanomedicine have spurred the use of various nanomaterials for developing multifunctional theranostic nanoplatforms . There are many inorganic nanocomposites that have been reported, such as iron oxide‐based, Au‐based, Pd‐based, and transition metal disulfide‐based nanoparticles (NPs) or their combination . However, most of these nanoplatforms are far from satisfactory with respect to their biostability, biocompatibility, and feasibility of fabrication, which have prevented them from achieving further clinical fulfillment.…”

Section: Introductionmentioning

confidence: 99%

A Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis

Wang

Lin

Chi

et al. 2018

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The need for better imaging assisted cancer therapy calls for new biocompatible agents with excellent imaging and therapeutic capabilities. This study successfully fabricates albumin-cooperated human serum albumin (HSA)-GGD-ICG nanoparticles (NPs), which are comprised of a magnetic resonance (MR) contrast agent, glycyrrhetinic-acid-modified gadolinium (III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (GGD), and a fluorescence (FL) dye, indocyanine green (ICG), for multimodal MR/FL imaging assisted cancer therapy. These HSA-GGD-ICG NPs with excellent biocompatibility are stable under physiological conditions, and exhibit enhanced T contrast capability and improved fluorescence imaging capacity. In vitro experiments reveal an apparent effect of the NPs in killing tumor cells under low laser irradiation, due to the enhanced photothermal conversion efficiency (≈85.1%). Importantly, multimodal MR/FL imaging clearly shows the in vivo behaviors and the efficiency of tumor accumulation of HSA-GGD-ICG NPs, as confirmed by a pharmacokinetic study. With the guidance of multimodal imaging, photothermal therapy is subsequently conducted, which demonstrates again high photothermal conversion capability for eliminating tumors without relapse. Notably, real-time monitoring of tumor ablation for prognosis and therapy evaluation is also achieved by MR imaging. This strategy of constructing nanoplatforms through albumin-mediated methods is both convenient and efficient, which would enlighten the design of multimodal imaging assisted cancer therapy for potential clinical translation.

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“…As a result, no single imaging modality is able to provide thorough preclinical information, making it difficult to obtain precise disease diagnoses. Thus, merging several imaging modalities into an "all-in-one" system can tremendously improve sensitivity and provide the better resolution needed for the detection of diseases, while overcoming limitations of a single modality alone 10 .…”

mentioning

confidence: 99%

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Kostiv

Kučka

Lobaz

et al. 2020

Sci Rep

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Abstract“All-in-one” multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.

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“All‐in‐One” Nanoparticles for Trimodality Imaging‐Guided Intracellular Photo‐magnetic Hyperthermia Therapy under Intravenous Administration

Cited by 95 publications

References 39 publications

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

A Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

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