All-in-one calcium nanoflowers for dual outputs biosensor: A simultaneous strategy for depression drug evaluation and non-invasive stress assessment

Yang, Shengnan; Dai, Fuju; Lu, Lina; Yin, Mengai; Xue, Lan; Feng, Wei; Li, Binshuai; Jiao, Jun; Chen, Qiang

doi:10.1016/j.bios.2022.114655

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…13 Examples of chronic stress conditions include depression, 14 anxiety, 15 osteoporosis, 16 schizophrenia, 17 cancer, diabetes, Cushing's, cardiovascular and autoimmune diseases. [18][19][20][21][22][23][24] A worldwide increase of chronic stress over the last years was recently reported, probably due to the COVID-19 pandemic, leading to anxiety conditions. 25 Cortisol analysis can be performed in the laboratory by analytical techniques, mainly based on mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Cortisol sensing by optical sensors

Santonocito,

Puglisi,

Cavallaro

et al. 2024

Analyst

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Section: Introductionmentioning

confidence: 99%

Cortisol sensing by optical sensors

Santonocito,

Puglisi,

Cavallaro

et al. 2024

Analyst

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“…Very recently, Chen and co-workers developed a nanosensor based on calcium nanoflowers mixed with horseradish peroxidase, streptavidin, and α-amylase for cortisol detection, with a limit of detection of 95.5 pg/mL and response in the range of 0.33–1000 ng/mL [ 57 ]. They used this new sensor in rat serum, human urine, and saliva.…”

Section: Optical Nanosensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Nanomaterials for Cortisol Sensing

Sfrazzetto

Santonocito

2022

Nanomaterials

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Space represents one of the most dangerous environments for humans, which can be affected by high stress levels. This can lead to severe physiological problems, such as headaches, gastrointestinal disorders, anxiety, hypertension, depression, and coronary heart diseases. During a stress condition, the human body produces specific hormones, such as dopamine, adrenaline, noradrenaline, and cortisol. In particular, the control of cortisol levels can be related to the stress level of an astronaut, particularly during a long-term space mission. The common analytical methods (HPLC, GC-MS) cannot be used in an extreme environment, such as a space station, due to the steric hindrance of the instruments and the absence of gravity. For these reasons, the development of smart sensing devices with a facile and fast analytical protocol can be extremely useful for space applications. This review summarizes the recent (from 2011) miniaturized sensoristic devices based on nanomaterials (gold and carbon nanoparticles, nanotubes, nanowires, nano-electrodes), which allow rapid and real-time analyses of cortisol levels in biological samples (such as saliva, urine, sweat, and plasma), to monitor the health conditions of humans under extreme stress conditions.

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“…[7] In addition, several common diseases are related to the altered homeostasis of cortisol, such as depression, anxiety, osteoporosis, but also critical pathologies, such as schizophrenia, cancer, diabetes, Cushing's, cardiovascular and autoimmune diseases. [8] For these reasons, monitoring of cortisol levels is of extreme interest, to prevent and avoid the arise of these diseases. Classical analytical instrumental techniques, based on HPLC combined with mass spectrometry, [9] are extremely selective and sensitive, but suffer in the practical and daily aspects, such as the constant and self-monitoring of cortisol levels.…”

Section: Introductionmentioning

confidence: 99%

“…However, under stress conditions, these levels can reach up to nine times higher than physiological levels [7] . In addition, several common diseases are related to the altered homeostasis of cortisol, such as depression, anxiety, osteoporosis, but also critical pathologies, such as schizophrenia, cancer, diabetes, Cushing's, cardiovascular and autoimmune diseases [8] . For these reasons, monitoring of cortisol levels is of extreme interest, to prevent and avoid the arise of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Smartphone‐Based Sensing of Cortisol by Functionalized Rhodamine Probes

Santonocito,

Cavallaro,

Puglisi

et al. 2024

Chemistry A European J

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During a stress condition, the human body synthesizes catecholamine neurotransmitters and specific hormones (called “stress hormones”), the most important of which is cortisol. The monitoring of cortisol levels should be extremely important to control the stress levels, and for this reason, it shows important medical applications. The common analytical methods (HPLC, GC‐MS) cannot be used in real life, due to the bulky size of the instruments and the necessity of specialized personnel. Molecular probes solve these problems due to their fast and easy use. The synthesis of new fluorescent rhodamine probes, able to interact by non‐covalent interactions with cortisol, the recognition properties in solution as well as in solid state by Strip Test, using a smartphone as detector, are here reported. DFT calculations and FT‐IR measurements suggest the formation of supramolecular complexes through hydrogen bonds as main non‐covalent interaction. The present study represents one of the first sensor, based on synthetical chemical receptors, able to detect cortisol in a linear range from 1 mM to 1 pM, based on non‐covalent molecular recognition and paves the way to the realization of practical point‐of‐care device for the monitoring of cortisol in real live.

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All-in-one calcium nanoflowers for dual outputs biosensor: A simultaneous strategy for depression drug evaluation and non-invasive stress assessment

Cited by 11 publications

References 29 publications

Cortisol sensing by optical sensors

Cortisol sensing by optical sensors

Nanomaterials for Cortisol Sensing

Smartphone‐Based Sensing of Cortisol by Functionalized Rhodamine Probes

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