All‐In‐One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer

Gong, Liuyun; Zhang, Yujie; Zhao, Jun; Zhang, Yilei; Tu, Kangsheng; Jiao, Libin; Xu, Qiuran; Zhang, Mingzhen; Han, Suxia

doi:10.1002/smll.202205198

Cited by 20 publications

(20 citation statements)

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“…To test our hypothesis, we investigated the Fe 3+ release through the disassembly of FPH at relatively acidic (pH 5.5) or reductive (10 mM GSH) settings, which mimicked the extracellular matrix and the intracellular environment, respectively. Under this condition, FPH exhibited significant enhancements in production rates of Fe 3+ (cumulative Fe 3+ release was 42.3% or 55.1% at 48 h post-treatment at pH 5.5 or with 10 mM GSH, respectively) owing to reduced coordination, while insignificant release occurred at pH 7.4 (Figure B). Fe 3+ endows FPH with a robust ferroptosis in cancer cells.…”

Section: Resultsmentioning

confidence: 97%

Remodeling the Tumor Microenvironment with Core–Shell Nanosensitizer Featuring Dual-Modal Imaging and Multimodal Therapy for Breast Cancer

Hou

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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To improve the efficiency of radiation therapy (RT) for breast cancer, a designable multifunctional core–shell nanocomposite of FeP@Pt is constructed using Fe(III)-polydopamine (denoted as FeP) as the core and platinum particles (Pt) as the shell. The hybrid structure is further covered with hyaluronic acid (HA) to give the final nanoplatform of FeP@Pt@HA (denoted as FPH). FPH exhibits good biological stability, prolongs blood circulation time, and is simultaneously endowed with tumor-targeting ability. With CD44-mediated endocytosis of HA, FPH can be internalized by cancer cells and activated by the tumor microenvironment (TME). The redox reaction between Fe3+ in FPH and endogenous glutathione (GSH) or/and hydrogen peroxide (H2O2) initiates ferroptosis therapy by promoting GSH exhaustion and •OH generation. Moreover, FPH has excellent photothermal conversion efficiency and can absorb near-infrared laser energy to promote the above catalytic reaction as well as to achieve photothermal therapy (PTT). Ferroptosis therapy and PTT are further accompanied by the catalase activity of Pt nanoshells to accelerate O2 production and the high X-ray attenuation coefficient of Pt for enhanced radiotherapy (RT). Apart from the therapeutic modalities, FPH exhibits dual-modal contrast enhancement in infrared (IR) thermal imaging and computed tomography (CT) imaging, offering potential in imaging-guided cancer therapy. In this article, the nanoplatform can remodel the TME through the production of O2, GSH- and H2O2-depletion, coenhanced PTT, ferroptosis, and RT. This multimodal nanoplatform is anticipated to shed light on the design of TME-activatable materials to enhance the synergism of treatment results and enable the establishment of efficient nanomedicine.

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Section: Resultsmentioning

confidence: 97%

Remodeling the Tumor Microenvironment with Core–Shell Nanosensitizer Featuring Dual-Modal Imaging and Multimodal Therapy for Breast Cancer

Hou

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…[67] It was reported that PtNPs can catalyze the decomposition of high content H 2 O 2 to produce oxygen, and the available oxygen can stabilize DNA damages caused by radiation to prevent DNA repair by cells, thereby improving the efficiency of RT. [68] Metal Pt with a high atomic number (Z) has been developed as a potential radio-sensitizer, which can effectively emit electron radiation by interacting with X-rays in tumors, thereby maximizing the radiation dose of cancer cells. Choi et al designed a porous PtNPs with great potential to enhance RT by combining the advantages of high-Z element with the oxygen generation ability.…”

Section: Combination Of Platinum Drugs With Radiotherapymentioning

confidence: 99%

Recent Advances of Platinum‐Based Anticancer Complexes in Combinational Multimodal Therapy

Zhong

Pan

et al. 2023

Adv Healthcare Materials

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Platinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit their clinical applications. Thus, the exploration on appropriate methods and strategies to overcome the limitations of traditional platinum drugs becomes extremely necessary. Combination therapy of platinum drugs can inhibit tumor growth and metastasis in an additive or synergistic manner, and can potentially reduce the systemic toxicity of platinum drugs and overcome platinum‐resistance. This review summarizes the various modalities and current progress in platinum‐based combination therapy. The synthetic strategies and therapeutic effects of some platinum‐based anticancer complexes in the combination of platinum drugs with gene editing, ROS‐based therapy, thermal therapy, immunotherapy, biological modelling, photoactivation, supramolecular self‐assembly and imaging modality are briefly described. Their potential challenges and prospects are also discussed. It is hoped that this review will inspire researchers to have more ideas for the future development of highly effective platinum‐based anti‐cancer complexes.

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“…First, NPs with catalase or metallomimetic catalase activity can promote the generation of endogenous O 2 from high levels of H 2 O 2 in the TME. 49,73,113,114 For example, Duo and co-workers synthesized MnO 2 -coated mesoporous SiO 2 NPs as PS carriers, and then platelet membranes were wrapped on their surface. MnO 2 with catalase-like activity can decompose H 2 O 2 in the acidic TME to produce water and O 2 , which can relieve local hypoxia and enhance the PDT therapy effect.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Colorectal cancer therapy mediated by nanomedicines

Zhang

Song

et al. 2023

Chem. Commun.

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All‐In‐One Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for Synergistically Enhanced Radiotherapy of Colon Cancer

Cited by 20 publications

References 0 publications

Remodeling the Tumor Microenvironment with Core–Shell Nanosensitizer Featuring Dual-Modal Imaging and Multimodal Therapy for Breast Cancer

Remodeling the Tumor Microenvironment with Core–Shell Nanosensitizer Featuring Dual-Modal Imaging and Multimodal Therapy for Breast Cancer

Recent Advances of Platinum‐Based Anticancer Complexes in Combinational Multimodal Therapy

Colorectal cancer therapy mediated by nanomedicines

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