All-fiber probes for endoscopic optical coherence tomography of the large airways

Balakrishnan, Santosh; Oldenburg, Amy L.

doi:10.1364/ao.431010

Cited by 2 publications

(4 citation statements)

References 30 publications

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“…One advantage of the GBLP is the ability to achieve longer working distances for those smaller diameter probes with low NA and large spot sizes. This has already been experimentally verified for OCT imaging in the upper airway [19]; similar imaging performance cannot be achieved using a GFP or BLP with the same small footprint. Such low-NA performance is possible using GRIN lenses; however, discrete lenses are bulkier and fabricated into a probe in a time-consuming, multistep procedure that is prone to alignment errors.…”

Section: A Gblp Vs Blp and Gfpmentioning

confidence: 67%

“…Finally, as already mentioned, the GBLP design presented in this work has been already experimentally validated in the low-NA regime [19]. The authors presented their hybrid probe with diameter greater than 0.5 mm and WD of >14 mm.…”

Section: Gblp Vs Other Fiber Probesmentioning

confidence: 81%

“…One approach to expand the performance parameter range of achievable designs, borrowed from the design of bulk optics, is to use multiple refractive elements -similar to the approach used in the design of long-working-distance objective lenses [18]. This idea was recently explored in [19] for designing longworking-distance probes for low-NA imaging of large airways. In fact, combining multiple focusing elements offers superior performance over a wider range of NAs and for many other imaging regimes and targets.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

Karnowski¹,

Untracht

Hackmann

et al. 2022

IEEE Photonics J.

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All-fiber-optic imaging microendoscopes are emerging as an important tool in bioimaging studies, but physical limitations constrain the achievable beam characteristics of designs using a single focusing element. These constraints are especially relevant for applications that require a long working distance, high resolution, and/or minimal probe diameter. Through detailed analysis based on ABCD matrix modelling, we show that side-viewing probes combining a graded-index fiber (GRIN) with a ball lens -GRIN-ball-lens probes (GBLPs) -offer superior performance over a range of numerical apertures and pave the way for a broader range of imaging applications. The performance of side-viewing GBPLs designed for 1300-nm optical coherence tomography imaging is compared against commonly used single-focusing-element all-fiber side-viewing probe designs, namely, ball-lens probes (BLPs) and GRIN-fiber probes (GFPs). All possible realizations of this novel probe design and their impact on the requisite design tradeoffs are investigated, including the impact on probe performance of fabrication error and the refractive index of the surrounding medium. Applications of GBLPs, including ultra-high-resolution (sub-2 micrometer) miniature probes for micro-endomicroscopy, are discussed.

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Section: A Gblp Vs Blp and Gfpmentioning

confidence: 67%

Section: Gblp Vs Other Fiber Probesmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

Karnowski¹,

Untracht

Hackmann

et al. 2022

IEEE Photonics J.

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“…The insertion loss of the probe is reduced, ensuring much higher signal-to-noise ratio of OCT performance. Moreover, the outer diameter of the catheter can be reduced to a small size [17,32,33].…”

Section: Imaging Cathetermentioning

confidence: 99%

Endoscopic optical coherence tomography angiography using an externally driving catheter

Gao

Chen

et al. 2023

Journal of Biophotonics

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Endoscopic optical coherence tomography (OCT) is an imaging modality that enables cross-sectional subsurface imaging of tubular organs and cavities.Recently, endoscopic OCT angiography (OCTA) was successfully achieved in distal scanning systems using an internal-motor-driving catheter. In conventional OCT systems using externally driving catheters, the mechanical instability in the proximal actuation causes difficulties for differentiating capillaries in tissues. In this study, OCTA in an endoscopic OCT system using an externalmotor-driving catheter was proposed. Blood vessels were visualized by using a high-stability inter-A-scan scheme and the spatiotemporal singular value decomposition algorithm. It is not limited by nonuniform rotation distortion caused by the catheter and physiological motion artifacts. Results show that microvasculature in a custom-made microfluidic phantom and the submucosal capillaries in the mouse rectum are successfully visualized. Furthermore, OCTA using a catheter with a small size (outer diameter less than 1 mm) makes it possible for early diagnosis of narrow lumens, such as pancreatic and bile duct cancers.

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All-fiber probes for endoscopic optical coherence tomography of the large airways

Cited by 2 publications

References 30 publications

Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

Superior Imaging Performance of All-Fiber, Two-Focusing-Element Microendoscopes

Endoscopic optical coherence tomography angiography using an externally driving catheter

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