Emerging M-Health technologies provide fundamentally different ways of looking at tailored communication technology. As a result, tailored communications research is poised at a crossroads. It needs to both build on and break away from existing frameworks into new territory, realizing the necessary commitment to theory-driven research at basic, methodological, clinical, and applied levels. In this context, the revolution of M-Health holds great promise in both health care and public health. The chapter envisions tailored M-Health communication in the context of patient-centered care, as it remains to be seen whether the revolution in M-Health will provide the tools to engineer sufficient impact on patient-centered care and tailored communication.