All CMOS low power platform for dielectrophoresis bio-analysis

Enteshari, Ali; Jullien, G.A.; Yadid-Pecht, Orly; Kaler, K.V.I.S.

doi:10.1109/esscir.2005.1541629

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Techniques under consideration include use of photodiodes and read out circuitry imbedded within each cell to detect the difference in received light that could indicated whether or not something is sitting on top of that cell. Also, popular [2], [3], [9]- [11] and under consideration for use is capacitive effects to detect the presense or absence of a droplet over an electrode. The analog electrode driver circuit described above could be reconfigured into a sense amp and used to detect the difference between the charge stored in a dummy cell and that present at the electrode under examination, similar to that done with commercial dynamic memory.…”

Section: Discussionmentioning

confidence: 99%

“…Determination of chemical and cell characteristics by electronic means using microliter volumes, such as the sorting of cancer cells, has been demonstrated [5]. Other examples of the application of these specific ideas have also been reported, for example [9]- [11]. The integrated circuit (IC) engine presented here is designed for maximum flexibility in handling a wide variety of microfluidic operations and includes electrode excitation voltages that can be set to any value between nominally 3.3-130 V at a wide range of frequencies.…”

Section: Introductionmentioning

confidence: 97%

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A High-Voltage SOI CMOS Exciter Chip for a Programmable Fluidic Processor System

Current

Yuk

McConaghy

et al. 2007

IEEE Trans. Biomed. Circuits Syst.

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A high-voltage (HV) integrated circuit has been demonstrated to transport fluidic droplet samples on programmable paths across the array of driving electrodes on its hydrophobically coated surface. This exciter chip is the engine for dielectrophoresis (DEP)-based micro-fluidic lab-on-a-chip systems, creating field excitations that inject and move fluidic droplets onto and about the manipulation surface. The architecture of this chip is expandable to arrays of N X N identical HV electrode driver circuits and electrodes. The exciter chip is programmable in several senses. The routes of multiple droplets may be set arbitrarily within the bounds of the electrode array. The electrode excitation waveform voltage amplitude, phase, and frequency may be adjusted based on the system configuration and the signal required to manipulate a particular fluid droplet composition. The voltage amplitude of the electrode excitation waveform can be set from the minimum logic level up to the maximum limit of the breakdown voltage of the fabrication technology. The frequency of the electrode excitation waveform can also be set independently of its voltage, up to a maximum depending upon the type of droplets that must be driven. The exciter chip can be coated and its oxide surface used as the droplet manipulation surface or it can be used with a top-mounted, enclosed fluidic chamber consisting of a variety of materials. The HV capability of the exciter chip allows the generated DEP forces to penetrate into the enclosed chamber region and an adjustable voltage amplitude can accommodate a variety of chamber floor thicknesses. This demonstration exciter chip has a 32 x 32 array of nominally 100 V electrode drivers that are individually programmable at each time point in the procedure to either of two phases: 0deg and 180deg with respect to the reference clock. For this demonstration chip, while operating the electrodes with a 100-V peak-to-peak periodic waveform, the maximum HV electrode waveform frequency is about 200 Hz; and standard 5-V CMOS logic data communication rate is variable up to 250 kHz. This HV demonstration chip is fabricated in a 130-V 1.0-mum SOI CMOS fabrication technology, dissipates a maximum of 1.87 W, and is about 10.4 mm x 8.2 mm.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

A High-Voltage SOI CMOS Exciter Chip for a Programmable Fluidic Processor System

Current

Yuk

McConaghy

et al. 2007

IEEE Trans. Biomed. Circuits Syst.

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“…It can run as a stand-alone module, be integrated as a block into Lab-on-Chip designs or be the base design to develop customizable systems, allowing for integration with such recent proposals and designs as presented in [9] [10]. …”

Section: Related Workmentioning

confidence: 99%

“…[9] 4 Sine, sweep 1KHz-5MHz Manipulate poly-styrene beads [11] +-6V, 200KHz , 2 superimposed frequencies…”

Section: Summary Conclusion and Future Workmentioning

confidence: 99%

A programmable and configurable multi-port System-on-Chip for stimulating electrokinetically-driven microfluidic devices

Lopez

Gerstlauer

Ávila

et al. 2011

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Recent research has demonstrated the use of microfluidic devices and electro-kinetics in areas such as medicine, genetics, embryology, epidemiology and pollution analysis, where manipulation of particles suspended in liquid media is required. Micro-fabrication technology has made it possible to increase system complexity and functionality by allowing integration of different processing and analysis stages in a single chip. However, fully integrated and autonomous microfluidic systems supporting ad-hoc stimulation have yet to be developed. This paper presents a flexible, configurable and programmable stimulator for electro-kinetically driven microfluidic devices. The stimulator is a dedicated System-onChip (SoC) architecture that generates sine, triangle, and sawtooth signals within a frequency range of 1Hz to 20 MHz, capable of delivering single, dual, and superimposed waveforms, in a user defined test sequence for a selected time period. The system is designed to be integrated into complete, autonomous Lab-on-Chip, portable or implantable devices. As such, it is expected to help significantly advance current and future research on particle manipulation.

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“…Fabricating labs-on-chips using a 3D process allows manufacturers to take advantage of the same benefits that are inherent to conventional 3D chips, such as a reduction in average interconnect length [2]. In many instances, such as the lab-on-chip presented in this paper, the transducers are placed in very large arrays [3], [4]. As these arrays become more and more dense, they become more difficult to floorplan and route.…”

Section: Introductionmentioning

confidence: 96%

Three-dimensional integrated circuits for lab-on-chip dielectrophoresis of nanometer scale particles

Dickerson

Noyola

Levitan

et al. 2007

Microfluidics, BioMEMS, and Medical Microsystems V

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In this paper, we present a mixed-technology micro-system for electronically manipulating and optically detecting virusscale particles in fluids that is designed using 3D integrated circuit technology. During the 3D fabrication process, the top-most chip tier is assembled upside down and the substrate material is removed. This places the polysilicon layer, which is used to create geometries with the process' minimum feature size, in close proximity to a fluid channel etched into the top of the stack. By taking advantage of these processing features inherent to "3D chip-stacking" technology, we create electrode arrays that have a gap spacing of 270 nm. Using 3D CMOS technology also provides the ability to densely integrate analog and digital control circuitry for the electrodes by using the additional levels of the chip stack. We show simulations of the system with a physical model of a Kaposi's sarcoma-associated herpes virus, which has a radius of approximately 125 nm, being dielectrophoretically arranged into striped patterns. We also discuss how these striped patterns of trapped nanometer scale particles create an effective diffraction grating which can then be sensed with macro-scale optical techniques.

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All CMOS low power platform for dielectrophoresis bio-analysis

Cited by 4 publications

References 6 publications

A High-Voltage SOI CMOS Exciter Chip for a Programmable Fluidic Processor System

A High-Voltage SOI CMOS Exciter Chip for a Programmable Fluidic Processor System

A programmable and configurable multi-port System-on-Chip for stimulating electrokinetically-driven microfluidic devices

Three-dimensional integrated circuits for lab-on-chip dielectrophoresis of nanometer scale particles

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