All-cause mortality in treated HIV-infected adults with CD4 &gt;=500/mm3 compared with the general population: evidence from a large European observational cohort collaboration

Lewden, Charlotte; Bouteloup, Vincent; Wit, Stéphane De; Sabin, Caroline; Mocroft, Amanda; Wasmuth, Jan Christian; Sighem, Ard van; Kirk, Ole; Obel, Niels; Panos, George; Ghosn, Jade; Dabis, François; Mary‐Krause, Murielle; Leport, Catherine; Pérez‐Hoyos, S.; Sobrino-Vegas, Paz; Stephan, Christoph; Castagna, Antonella; Antinori, Andrea; Monforte, Antonella d’Arminio; Torti, Carlo; Mussini, Cristina; Isern, Virginia; Calmy, Alexandra; Teira, Ramón; Egger, Matthias; Grarup, Jesper; Chêne, Geneviève

doi:10.1093/ije/dyr164

Cited by 222 publications

(98 citation statements)

References 29 publications

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“…8 Non-IDU HIV-infected individuals who achieved high CD4 cell counts after starting cART were found to have mortality patterns similar to those in the general population. Mortality was found to be persistently higher in individuals with a prior AIDS diagnosis 9 , while the incidence of AIDS events continued to decline until CD4 cell counts were greater than 750 cells/mm 3 . 10 In patients with viral suppression, the risk of a new AIDS events or death followed a CD4 cell count gradient, even benefiting those with a CD4 cell count ≥500 cells/mm 3 .…”

Section: Prognosis and The Effect Of Artmentioning

confidence: 94%

Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord

Chêne

Phillips²,

Costagliola

et al. 2016

Int. J. Epidemiol.

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Section: Prognosis and The Effect Of Artmentioning

confidence: 94%

Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord

Chêne

Phillips²,

Costagliola

et al. 2016

Int. J. Epidemiol.

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“…The introduction of highly active antiretroviral therapy (HAART) has changed the course of HIV infection, increasing life expectancy (1), but on the other hand making more prevalent diseases such as osteoporosis, neurocognitive impairment, renal disease, and cardiovascular events (2). Among these associated comorbidities, HIV-infected patients frequently experience metabolic complications such as insulin resistance (IR), increasing the risk of diabetes mellitus (DM) (3).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of insulin resistance and risk of diabetes mellitus in HIV-infected patients receiving current antiretroviral drugs

Araújo

Bañón

Machuca

et al. 2014

European Journal of Endocrinology

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Objective: HIV-infected patients had a higher prevalence of insulin resistance (IR) and risk of diabetes mellitus (DM) than that observed in healthy controls, but there are no data about the current prevalence considering the changes in HIV presentation and the use of newer antiretroviral drugs. Design: Longitudinal study which involved 265 HIV patients without DM, receiving first (nZ71) and advanced lines of antiretroviral therapy (nZ194). Methods: Prevalence of IR according to clinical and anthropometric variables, including dual X-ray absorptiometry (DXA) scan evaluation. IR was defined as homeostasis model assessment of IR R3.8. Incident DM was assessed during the follow-up. Results: First-line patients had a short time of HIV infection, less hepatitis C virus coinfection, and received mainly an efavirenz-based regimen. Overall, the prevalence of IR was 21% (55 patients, 6% in first-line, 27% in pretreated). In a logistic regression analysis, significant associations were found between the waist/hip circumference ratio (RR 10; 95% CI 1.66-16; P!0.01, per unit), and central fat in percentage (RR 1.08; 95% CI 1.01-1.17; PZ0.04, per unit) as evaluated by DXA, and IR. During 770.8 patient-years, DM was diagnosed in 8% (22 patients), mostly in pretreated patients (10 vs 4%; PZ0.1). Thus, the overall rate of incident DM was 2.85 per 100 person-years, mostly in previous IR (10.39 vs 0.82/100 person-years; PZ0.01). Conclusions: A lower prevalence of IR is observed in the current HIV-infected patients with fewer risk factors and receiving newer antiretroviral drugs. IR continues to identify patients at high risk for developing DM in the short term.

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“…Estudos indicam que, em alguns anos, a expectativa de vida dos portadores de HIV vai se igualar à dos indivíduos não portadores 14,15 .…”

Section: Tabela 2 -Número De Indivíduos Acometidos Por Comorbidades unclassified

“…Ao passo que, aumentando a expectativa de vida, outros problemas crônicos podem surgir, principalmente relacionados aos usos dos antirretrovirais 14 .…”

Section: Tabela 2 -Número De Indivíduos Acometidos Por Comorbidades unclassified

Mortalidade por AIDS e fatores associados no município de Ponta Grossa, Paraná: 2008-2015

Brojan¹,

Müller²,

Brasil³

2018

RBPS

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All-cause mortality in treated HIV-infected adults with CD4 >=500/mm3 compared with the general population: evidence from a large European observational cohort collaboration

Abstract: Mortality patterns in most non-IDU HIV-infected individuals with high CD4 counts on cART are similar to those in the general population. The persistent role of a prior AIDS diagnosis underlines the importance of early diagnosis of HIV infection.

Cited by 222 publications

References 29 publications

Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord

Cohort Profile: Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord

Prevalence of insulin resistance and risk of diabetes mellitus in HIV-infected patients receiving current antiretroviral drugs

Mortalidade por AIDS e fatores associados no município de Ponta Grossa, Paraná: 2008-2015

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