All about toxoplasmosis in cats: the last decade

Dubey, J. P.; Cerqueira‐Cézar, Camila K.; Murata, Fernando Henrique Antunes; Kwok, O. C. H.; Yang, Yurong; Su, Chunlei

doi:10.1016/j.vetpar.2020.109145

Cited by 108 publications

(118 citation statements)

References 264 publications

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“…Considering cats, age was the only risk factor identified, with T. gondii seroprevalence rising significantly as the cat's age increased. This finding is consistent with those previously reported in this host species (reviewed in Dubey et al, 2020a). Age-related seropositivity could reflect the long persistence of anti-T. gondii antibodies in the animal and/or the highest probability of having contacted with the parasite along its lifetime (Cano-Terriza et al, 2016;Rengifo-Herrera et al, 2017).…”

Section: Discussionsupporting

confidence: 92%

“…Thus, taking into account the growth of the dog and cat population in Thailand (OIE, 2019), the particularly close contact between these species and humans in the study area (Savvides, 2013;Toukhsati et al, 2015) and the seroprevalence detected in this study, outdoor cats and dogs in Bangkok should be considered as hosts with a possibly significant epidemiological role in the maintenance of T. gondii. Regarding other Asian countries, a study carried out in China showed higher seroprevalences (8.2-30.9%) in dogs using the same technique (MAT) on a similar sample size (Dubey et al, 2020b); in cats, slightly higher seroprevalences have also been described using MAT on a similar sample size in China (19.3-24.4%) and much higher seroprevalence has been reported in Qatar (82%) (Dubey et al, 2020a).…”

Section: Discussionmentioning

confidence: 94%

“…The authors detected seroconversion rates of 0.42-0.96 per cat and year. No such studies were performed elsewhere (Dubey et al, 2020a(Dubey et al, , 2020b.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Toxoplasma gondii in outdoor dogs and cats in Bangkok, Thailand

et al. 2021

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

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Seroprevalence of Toxoplasma gondii in outdoor dogs and cats in Bangkok, Thailand

et al. 2021

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“…Felids as final host play an irreplaceable role for T. gondii life cycle that exclusively yield and excrete oocysts in their faeces, contaminating soil, water and food [6][7][8]10 . According to our findings, 37.5% of domestic cats showed exposure to T. gondii and 2.6% were actively shedding T. gondii or T. gondii-like oocysts.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the domestic cats, and under the view of the available literature, the role of wild Felidae in the epidemiology of T. gondii should not be neglected 5 , 9 . Therefore, felids constitute the key element in the epidemiology of T. gondii since an individual can shed millions of oocyts that can spread the infection to many other susceptible hosts 10 . Several important outbreaks of human toxoplasmosis were epidemiologically linked to oocyst contamination of drinking water 11 – 13 .…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis

Hatam-Nahavandi

Calero‐Bernal

Rahimi

et al. 2021

Sci Rep

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Felidae as definitive hosts for Toxoplasma gondii play a major role in transmission to all warm-blooded animals trough oocysts dissemination. Therefore the current comprehensive study was performed to determine the global status of T. gondii infection in domestic and wild felids aiming to provide comprehensive data of interest for further intervention approaching the One Health perspective. Different databases were searched by utilizing particular key words for publications related to T. gondii infecting domestic and wild feline host species, worldwide, from 1970 to 2020. The review of 337 reports showed that the seroprevalence of T. gondii in domestic cats and wild felids was estimated in 37.5% (95% CI 34.7–40.3) (I2 = 98.3%, P < 0.001) and 64% (95% CI 60–67.9) (I2 = 88%, P < 0.0001), respectively. The global pooled prevalence of oocysts in the fecal examined specimens from domestic cats was estimated in 2.6% (95% CI 1.9–3.3) (I2 = 96.1%, P < 0.0001), and that in fecal samples from wild felids was estimated in 2.4% (95% CI 1.1–4.2) (I2 = 86.4%, P < 0.0001). In addition, from 13,252 examined soil samples in 14 reviewed studies, the pooled occurrence of T. gondii oocysts was determined in 16.2% (95% CI 7.66–27.03%). The observed high rates of anti-T. gondii antibodies seroprevalence levels and oocyst excretion frequency in the felids, along with soil (environmental) contamination with oocysts may constitute a potential threat to animal and public health, and data will result of interest in further prophylaxis programs.

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Minireview: Applications of NMR‐based metabolomics for the detection and characterisation of toxoplasmosis in felids

Hunter

Wilson

2020

Analytical Science Advances

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Toxoplasmosis is an infection caused by the intercellular protozoan parasite Toxoplasma gondii. The parasite has the three‐stage life cycle: oocysts, tachyzoites, and bradyzoites. Felids are the only known hosts for the sexual reproduction of T. gondii and, therefore, play a crucial role in the transmission of toxoplasmosis. A single cat could spread the parasite to many hosts. Due to the intercellular nature of the parasite, T. gondii strongly depends on a host's metabolism in order to leverage carbon and nutrient sources. Therefore, the parasite could be detected in body fluids via observation and analysis of metabolic alterations. A range of analytical techniques such as nuclear magnetic resonance (NMR), mass spectrometry coupled with liquid chromatography, and Raman spectroscopy could be applied for the analysis of body fluids of infected animals. However, NMR consists of highly specific analytical techniques due to high reproducibility, availability of a variety of databases, and the ability to obtain the structures of unknown compounds. We present the current extent of NMR‐based metabolomics on felid toxoplasmosis and suggest future considerations.

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All about toxoplasmosis in cats: the last decade

Cited by 108 publications

References 264 publications

Seroprevalence of Toxoplasma gondii in outdoor dogs and cats in Bangkok, Thailand

Seroprevalence of Toxoplasma gondii in outdoor dogs and cats in Bangkok, Thailand

Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis

Minireview: Applications of NMR‐based metabolomics for the detection and characterisation of toxoplasmosis in felids

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