Alkylthiol self-assembled monolayers on Au(111) with tailored tail groups for attaching gold nanoparticles

Kutsenko, V. Ye.; Lopatina, Yaroslava Yu.; Bossard-Giannesini, Léo; Marchenko, Alexandr; Pluchery, Olivier; Snegir, Sergii

doi:10.1088/1361-6528/aa6e3d

Cited by 20 publications

(24 citation statements)

References 50 publications

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“…For the same time of modification (12 h), the higher peak current diminution (97 %) was detected for the SAM composed of HDT. Therefore, among the tested SAMs, HDT‐SAM was the best adsorbed and packed on the electrode surface. SAMs of alkanethiols on Au are one of the simplest way and best available surface modification for biosensors development since sulfur has strong affinity to Au and van der Waals inter‐chain interactions ensure SAM tight packing and stability .…”

Section: Resultssupporting

confidence: 46%

“…SAMs present several advantages such as easy formation, flexibility in functional control by changing the tail group and needed of low amount of biomolecules for immobilization . Moreover, SAMs can be coupled with gold nanoparticles (AuNPs) , which present unique physico‐chemical properties, such as high surface/volume ratio, high stability and good biological compatibility, making themselves an ideal base for biosensing platform . AuNPs also display excellent conduction characteristics and are easy to functionalize; AuNPs surface can be coated with an antibody by simple adsorption maintaining the bioactivity of the adsorbed biomolecules .…”

Section: Introductionmentioning

confidence: 99%

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Label‐free Voltammetric Immunosensor for Prostate Specific Antigen Detection

et al. 2018

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This work describes a sensitive voltammetric immunosensor for label‐free electroanalysis of the prostate specific antigen (PSA), the main biomarker of prostate cancer. A gold electrode was firstly modified with the optimum self‐assembled monolayer (SAM), 1,6‐hexanedithiol, followed by the subsequent adsorption of gold nanoparticles (AuNPs) and, then, the monoclonal antibody to recognize PSA was immobilized. The influence of the most significant experimental variables (SAM type and incubation time, AuNPs deposition, antibody concentration and bovine serum albumin immobilization) on the biosensor response was studied by microscopy and voltammetry techniques. The electroanalytical detection was based on the interaction between PSA antibody and PSA via square‐wave voltammetry using ferrocyanide/ferricyanide as electrochemical redox indicator. Using the proposed immunosensor, PSA was specifically detected within the linear range between 0.2 and 200 ng mL−1 with 0.01 ng mL−1 as limit of detection. The immunosensor allows accurate, reproducible and sensitive (22.7 % reduction mL ng−1) detection in a concentration range useful for clinical purposes.

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Section: Resultssupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Label‐free Voltammetric Immunosensor for Prostate Specific Antigen Detection

et al. 2018

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“…At 77 K, the peripheries of the kagome islands are often seen to vary between scans, indicating a significant level of molecular mobility. Combined with the lack of any noticeable herringbone distortion, we attribute this to the 3,9-Br 2 PXX molecules being weakly bound to the Au(111) surface (typically, strongly bound adsorbates result in a lifting or a significant distortion of the herringbone reconstruction [57][58][59][60]. Two mirror symmetric orientations of the kagome structures can be found, suggesting that the pro-chiral 3,9-Br 2 PXX molecules segregate into chiral domains upon adsorption.…”

Section: Resultsmentioning

confidence: 91%

Combining high-resolution scanning tunnelling microscopy and first-principles simulations to identify halogen bonding

et al. 2020

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Scanning tunnelling microscopy (STM) is commonly used to identify on-surface molecular self-assembled structures. However, its limited ability to reveal only the overall shape of molecules and their relative positions is not always enough to fully solve a supramolecular structure. Here, we analyse the assembly of a brominated polycyclic aromatic molecule on Au(111) and demonstrate that standard STM measurements cannot conclusively establish the nature of the intermolecular interactions. By performing high-resolution STM with a COfunctionalised tip, we clearly identify the location of rings and halogen atoms, determining that halogen bonding governs the assemblies. This is supported by density functional theory calculations that predict a stronger interaction energy for halogen rather than hydrogen bonding and by an electron density topology analysis that identifies characteristic features of halogen bonding. A similar approach should be able to solve many complex 2D supramolecular structures, and we predict its increasing use in molecular nanoscience at surfaces.

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“…Self-assembly of AuNPs on a micro-scale requires exploiting their high affinity toward specific surface functional groups. Gold substrates coated with dithiols, for instance, can efficiently anchor AuNPs [17,18]. The surface of glass, silicon, and indium tin oxide (ITO) pre-coated with (3-aminopropyl)trimethoxysilane (APTES) can efficiently attach AuNPs [19][20][21] as well as NPs made of Ag [22,23], SiO 2 [24], TiO 2 [25,26], Fe 2 O 3 [27,28], or Y-zeolites [29].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle Self-Aggregation on Surface with 1,6-Hexanedithiol Functionalization

et al. 2020

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Here we study the morphology and the optical properties of assemblies made of small (17 nm) gold nanoparticles (AuNPs) directly on silicon wafers coated with (3-aminopropyl)trimethoxysilane (APTES). We employed aliphatic 1,6-hexanedithiol (HDT) molecules to cross-link AuNPs during a two-stage precipitation procedure. The first immersion of the wafer in AuNP colloidal solution led mainly to the attachment of single particles with few inclusions of dimers and small aggregates. After the functionalization of precipitated NPs with HDT and after the second immersion in the colloidal solution of AuNP, we detected a sharp rise in the number of aggregates compared to single AuNPs and their dimers. The lateral size of the aggregates was about 100 nm, while some of them were larger than 1μm. We propose that the uncompensated dipole moment of the small aggregates appeared after the first precipitation and acts further as the driving force accelerating their further growth on the surface during the second precipitation. By having such inhomogeneous surface coating, the X-ray reciprocal space maps and modulation polarimetry showed well-distinguished signals from the single AuNPs and their dimers. From these observations, we concluded that the contribution from aggregated AuNPs does not hamper the detection and investigation of plasmonic effects for AuNP dimers. Meantime, using unpolarized and polarized light spectroscopy, the difference in the optical signals between the dimers, being formed because of self-aggregation and the one being cross-linked by means of HDT, was not detected.

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Alkylthiol self-assembled monolayers on Au(111) with tailored tail groups for attaching gold nanoparticles

Cited by 20 publications

References 50 publications

Label‐free Voltammetric Immunosensor for Prostate Specific Antigen Detection

Label‐free Voltammetric Immunosensor for Prostate Specific Antigen Detection

Combining high-resolution scanning tunnelling microscopy and first-principles simulations to identify halogen bonding

Gold Nanoparticle Self-Aggregation on Surface with 1,6-Hexanedithiol Functionalization

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