Alkylative Reduction of Titanium(IV) Isopropoxide with EtMgBr: Convenient Method for the Generation of Subvalent Titanium Alkoxide Reagents and Their Reactivity in Pinacol Coupling Reactions.

Abstract

A reagent combination of Ti(OiPr)4 and ethylmagnesium bromide generates low valent Ti(OiPr)3 which is readily used to transform carbonyl compounds into the corresponding pinacols. -(MATIUSHENKOV, E. A.; SOKOLOV, N. A.; KULINKOVICH*, O. G.; Synlett 2004, 1, 77-80; Dep. Org. Chem., Belarus State Univ., Minsk 220050, Belarus; Eng.) -Mais 19-032

Visible-Light-Promoted Reduction of Epoxides, Hydroxysulfonates, and Halohydrines with Alkyltitanium Alkoxides

“…D 2 O quenching of the reaction mixture after epoxide 6h reduction gave no deuterated product, which showed that the radical formation was followed by HAT. Reaction in THFd 8 gave no deuteration product as well. Finally, we detected partial incorporation of the isotopic label in 7h when titanium alkoxide 16 was used instead of Ti(OiPr) 4 .…”