Alkylating activity in food products—especially sauerkraut and sour fermented dairy products—after incubation with nitrite under quasi-gastric conditions

Groenen, Patricia J.T.A.; Busink, E.

doi:10.1016/0278-6915(88)90122-6

Cited by 15 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lower proportion of G:C>A:T transitions at CpG dinucleotides (attributed to spontaneous deamination of cytosine) identified in ESCC samples in this study is in line with previous studies from India [47] . Higher frequency of G:C>A:T transitions at non-CpG sites can be attributed to alkylating agents in food and environment [48] . Of note, nitrosamines in alcoholic beverages [49] and processed meat [50] are known to increase the risk of esophageal and stomach cancer, respectively.…”

Section: Discussionmentioning

confidence: 99%

TP53 Pro72 Allele Is Enriched in Oral Tongue Cancer and Frequently Mutated in Esophageal Cancer in India

et al. 2014

View full text Add to dashboard Cite

PurposeThe tumor suppressor p53 is known to be inactivated frequently in various cancers. In addition, germline polymorphisms in TP53 are known to affect protein function and influence risk of developing different types of cancers. In this study, we analyzed the association of TP53 Pro72Arg polymorphism with squamous cell carcinoma of oral tongue (SCCOT) and esophagus (ESCC) in India.MethodsWe assessed the distribution of TP53 Pro72Arg polymorphism in one hundred and fifteen and eighty two SCCOT and ESCC patients, respectively, with respect to one hundred and ten healthy controls from the same population. In addition, we analyzed association of the polymorphism with several clinico-pathological and molecular parameters.ResultsPro72 allele was significantly enriched in SCCOT patients compared to the healthy control group but neither allele was enriched in ESCC. Interestingly, Pro72 allele was preferentially mutated in ESCC which was confirmed by analysis of samples heterozygous for Pro72Arg.ConclusionsOur study revealed the association of Pro72 allele with SCCOT suggesting the effect of this polymorphism on SCCOT risk. Preferential mutation of Pro72 allele exclusively in ESCC indicates the need for further studies to understand the tissue specific effect of p53 polymorphism.

show abstract

Section: Discussionmentioning

confidence: 99%

TP53 Pro72 Allele Is Enriched in Oral Tongue Cancer and Frequently Mutated in Esophageal Cancer in India

et al. 2014

View full text Add to dashboard Cite

show abstract

“…13 Groenen et al found a strong alkylating activity in samples of sauerkraut after incubation with nitrite. 14 Walker et al (1996) analyzed the tyramine content of 51 food samples by means of liquid chromatography. They found a dangerously high concentration of tyramine at 7.75 mg/250 g in sauerkraut.…”

Section: Resultsmentioning

confidence: 99%

Regular Consumption of Sauerkraut and Its Effect on Human Health: A Bibliometric Analysis

Raak

Ostermann

Boehm

et al. 2014

Glob Adv Health Med

View full text Add to dashboard Cite

Background:Sauerkraut is one of the most common and oldest forms of preserving cabbage and can be traced back as a food source to the 4th century BC. It contains a large quantity of lactic acid and tyramines, as well as vitamins and minerals, and has few calories.Objective:We aimed to provide an overview regarding the evidence of the effects of sauerkraut on human health by means of a bibliometric analysis.Methodology:Electronic databases (Medline, AMED, CamBase, CamQuest, the Cochrane Central Register of Controlled Trials, the Database of Abstracts of Reviews of Effects, the Cochrane Database of Systematic Reviews, EMBASE, the Karger-Publisher and the Thieme-Publisher databases) were searched from their inception until September 2012.Results:The search revealed 139 publications ranging over a 90-year period from 1921 to 2012. The majority of publications originated from Europe (48.6%), followed by the United States (30.7%) and Asia (10%). More than half of the research (56.8%) focused on food analysis, and 23.7% evaluated the impact of sauerkraut on health, including risk factors or digestive well-being. Direct research in humans was almost constant over time at about 11.5%. The studies found that sauerkraut induced inflammation locally, but repeated intake may result in diarrhea. Some studies pointed out anticarcinogenic effects of sauerkraut, while others concentrated on the interaction with monoamine oxidase inhibitors (MAOIs).Discussion:Sauerkraut, one of the oldest traditional foods, has a variety of beneficial effects on human health. However, unwanted effects such as intolerance reactions must be considered when dealing with sauerkraut as a functional food.

show abstract

“…Additionally, for the first time, we found that several oncogenes are in the format of ecDNA amplicons in GCA patients and that different oncogenes could coamplify in the same ecDNA amplicon. Interestingly, we found oncogene ecDNA amplicons were associated with a high frequency of chromothripsis in our GCA cohort, and such a high frequency of chromothripsis in our cohort is likely due to high degree of DNA damage induced by nitrosamine exposure from a local diet [45][46][47][48][49][50] . We propose that local dietary habits from the geographic region may have contributed to ecDNA occurrence in our GCA cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence has demonstrated that nitrosamine is a very important factor for DNA alkylation, synthesis disorder, high instability and even DNA double strand breaks [45][46][47][48][49][50] . Thus, we suspected that nitrosamine exposure in our GCA cohort may accumulate DNA damage, potentially inducing a high frequency of chromothripsis.…”

Section: P7 6cmentioning

confidence: 99%

Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Zhao

Xing

Song

et al. 2021

Preprint

View full text Add to dashboard Cite

Extrachromosomal DNA plays an important role in oncogene amplification in tumour cells and poor outcomes across multiple cancers. However, the function of extrachromosomal DNA in gastric cardia adenocarcinoma (GCA) is very limited. Here, we investigated the availability and function of extrachromosomal DNA in GCA from a Chinese cohort of GCA using whole-genome sequencing (WGS), whole-exome sequencing (WES), and immunohistochemistry. For the first time, we identified the ecDNA amplicons present in most GCA patients, and found that some oncogenes are present as ecDNA amplicons in these patients. We found that oncogene ecDNA amplicons in the GCA cohort were associated with the chromothripsis process and may be induced by accumulated DNA damage due to local dietary habits in the geographic region. Strikingly, we observed diverse correlations between the presence of ecDNA oncogene amplicons and prognosis, where ERBB2 ecDNA amplicons correlated with good prognosis, EGFR ecDNA amplicons correlated with poor prognosis, and CCNE1 ecDNA amplicons did not correlate with prognosis. Large-scale ERBB2 immunohistochemistry results from 1668 GCA patients revealed that there was a positive correlation between the presence of ERBB2 and prognosis in 2-7-year survival; however, there was a negative correlation between the presence of ERBB2 and prognosis in 0-2-year survival. Our observations indicate that the presence of ERBB2 ecDNA in GCA patients may represent a good prognosis marker.

show abstract

Alkylating activity in food products—especially sauerkraut and sour fermented dairy products—after incubation with nitrite under quasi-gastric conditions

Cited by 15 publications

References 33 publications

TP53 Pro72 Allele Is Enriched in Oral Tongue Cancer and Frequently Mutated in Esophageal Cancer in India

TP53 Pro72 Allele Is Enriched in Oral Tongue Cancer and Frequently Mutated in Esophageal Cancer in India

Regular Consumption of Sauerkraut and Its Effect on Human Health: A Bibliometric Analysis

Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Contact Info

Product

Resources

About