Alkyl Thiolsulfinates

Small, LaVerne D.; Bailey, John Hays; Cavallito, Chester J.

doi:10.1021/ja01199a040

Cited by 194 publications

(88 citation statements)

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“…In addition, both cysteine and glutathione protected against allicin inhibition. Earlier work by Small et al (23) revealed that the thiosulfinate link (-SO-S-) was essential for bactericidal action. Wills (26) demonstrated that this functional group was also required for inhibition of succinic oxidase, with no inhibition observed with diallyl sulfide, diallyl disulfide, or diallyl sulfoxide.…”

Section: Resultsmentioning

confidence: 99%

In vitro mechanism of inhibition of bacterial cell growth by allicin

Feldberg

Chang

Kotik

et al. 1988

Antimicrob Agents Chemother

230

135

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Diallyl thiosulfinate (allicin) is the agent found in garlic which is responsible for the antibacterial and antifungal activity of extracts of this plant. The effect of bacteriostatic concentrations of allicin (0.2 to 0.5 mM) on the growth of Salmonella typhimurium revealed a pattern of inhibition characterized by: (i) a lag of approximately 15 min between addition of allicin and onset of inhibition, (ii) a transitory inhibition phase whose duration was proportional to allicin concentration and inversely proportional to culture density, (iii) a resumed growth phase which showed a lower rate of growth than in uninhibited controls, and (iv) an entry into stationary phase at a lower culture density. Whereas DNA and protein syntheses showed a delayed and partial inhibition by allicin, inhibition of RNA synthesis was immediate and total, suggesting that this is the primary target of allicin action.

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Section: Resultsmentioning

confidence: 99%

In vitro mechanism of inhibition of bacterial cell growth by allicin

Feldberg

Chang

Kotik

et al. 1988

Antimicrob Agents Chemother

230

135

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“…36) Allicin containing thiosulfinate chemotypes can react readily with cysteine to yield disulfide and sulfur dioxide. 37) Among the sulfur-containing compounds of garlic, allicin has been extensively studied as an active ingredient of garlic, 36) althought there is no report regarding how garlic modulates TLR signaling pathways for its mechanism of biological activity.…”

Section: Discussionmentioning

confidence: 99%

Garlic (Allium sativum) Extract Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization

Youn

Lim

Lee

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…The lung function was examined by whole-body plethysmography using the amount o f'compressed air' (ml) as parameter [6]. Thirty minutes later, 7 animals were fed with 100 mg/kg DPTS -synthesized according to the method of Small et al [7] -in olive oil, the other 7 with olive oil alone. One hour later all animals inhaled 1 pg PAF [3]; 90 min later the same histamine dose was given prior to PAF.…”

Section: Methodsmentioning

confidence: 99%

Antiasthmatic Effects of Onions

Dorsch¹,

Scharff²,

Bayer

et al. 1989

Int Arch Allergy Immunol

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Thiosulfinates are responsible for antiasthmatic and anti-inflammatory properties of onions. We tested the effect of diphenylthiosulfinate on platelet-activating factor (PAF)-induced bronchial hyperreactivity to histamine: According to a randomized crossover protocol, groups of 14 guinea pigs inhaled histamine, were then treated orally with either vehicle or with 10–100 mg/kg diphenylthiosulfinate, inhaled 1 µg PAF, and thereafter the same histamine dose given prior to PAF. In the control group the histamine response increased threefold; in the treated group the histamine response decreased. The effect of 100 mg diphenylthiosulfinate lasted 12 h. Antihistamine effects were not demonstrable in this test system. We conclude that thiosulfinates inhibit PAF-induced hyperreactivity.

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Alkyl Thiolsulfinates

Cited by 194 publications

References 0 publications

In vitro mechanism of inhibition of bacterial cell growth by allicin

In vitro mechanism of inhibition of bacterial cell growth by allicin

Garlic (Allium sativum) Extract Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization

Antiasthmatic Effects of Onions

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