Alkaloids ofCorydalis gigantea

Abstract

We have studied Corydalis gigantea Trautv. et Mey., family Papaveraceae [i], growing in the Far East.The plants were collected in the Krasnoarmeiskii region in the phase of mass vegetation.An evaporated methanolic extract of 17 kg of the herbage was treated with 5% sulfuric acid, the acid solution was made alkaline with 25% ammonia, and the bases were extracted with chloroform.The combined alkaloids (46.3 g) were separated by the usual method into fractions of phenolic (2.2 g) and nonphenolic (9 g) benzene-soluble bases and a benzene-insoluble fraction (35 g). The fraction of phenolic bases, on chromatography on a column of silica gel with elution by benzene-ethyl acetate (7:3) yielded 0.37 g of l-scoulerine, and elution with ethyl acetate gave 0.55 g of /-cheilanthifoline [2].Crystallization of the benzene-soluble nonphenolic bases yielded 0.64 g of L-adlumine and 1.24 g of protopine.By chromatography on a column of silica gel, the mother solutions yielded 0.13 g of sanguinarine, 0.09 g of dihydrosanguinarine, 1.17 g of d-bicuculline, and 0.14 g of /-adlumidine [3]. The structures of the other bases isolated are being studied. 1 10011. No part o f this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, elec tronic, J mechanical, photocopying, microfilming, recording or otherwise, without written permission o f the publisher. A copy o f this article is available f r o m the publisher f o r $7.50.

The Protopine Alkaloids

“…Typically, in TFA-J, C-5 appears at 25 ppm, C-6 at 56 ppm, C-8 at 59 ppm, 013 at 41 ppm and C-14 at 95 ppm, while the N-methyl carbon is near 46 ppm (131). (15) SOURCES: BERBERIDACEAE: Berberís (16) FUMARIACEAE: Corydalis (30,33,34,38,40,42,43,44,49,50,51,54,55,58,59,60,64,65,66,67,76,86,88,91,118,119,120,121) Dactylicapnos (61) Dicentra (38,52,56) Fumaria (1,29,47,57,68,69) P APA VE RACE AE: Argemone (2,25,26,114,115,116) Bocconia (103,122) Chelidonium (36,…”