Alkaloids of Tobacco.

Spectroscopic investigations into the acid–base properties of nicotine at different temperatures

“…The measurement of the pK a values of nicotine has been the subject of a number of investigations and the subject was examined by Jackson 9 and more recently by Banyasz. 10 Jackson evaluated that, with the use of potentiometric methodology, pK a1 ¼ 3.22 and pK a2 ¼ 8.11 (20 C, ionic strength not dened).…”

Vapor pressure data of nicotine, anabasine and cotinine using differential scanning calorimetry

“…The refractive index of lnicotine was n 20 d 1.5255-1.5285, the optical rotation was ½a 20 D À140 to À152 (given by the supplier). The melting point is presumed to be lower than À79 C [9].…”

Effect of the Tumor Promoter 12-O-TetradecanoyIphorbol-13-Acetate on the Rate of Disappearance of Nicotine from Mouse Skin

“…The absorption of nicotine from the tongue, rectum and eyes takes place in a few seconds [1], and this alkaloid appears to be rapidly absorbed by mouse skin. This is demonstrated by the fact that 2-5 min after application of nicotine, the mice became prostrate and remained so for 3-4 h. Since the mice became prostrate so soon after application of this alkaloid, physical contact or mutual grooming do not appear to be factors in the removal of nicotine from the skin.…”

“…Nicotine is one of the most violent poisons hardly inferior to hydrocyanic acid in toxic power and rapid ity of action [1], The absorption of nicotine takes place even in a few seconds from the tongue, rectum, the eyes and it is also absorbed from the skin [ 1 ]. In tobacco smoke both nicotine and the carcinogen benzo-(a)pyrcnc (BP) are toxic constituents [2,3], but the role of nicotine in the etiology of lung cancer in man or in animal carcinogenesis has not yet been determined.…”