Alkaloids of the seeds and pericarp ofSophora griffithii

Karakozova, S. A.; Abdusalamov, B. A.; Khazanovich, R. L.

doi:10.1007/bf00567731

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Identification of known compounds done on the basis of the spectroscopic data as well as a comparison with those found in the literature as argentine ( 15 ), [(3-hydroxy-6-pyridinyl)-methyl]-cytisine ( 16 ), N -acetonylcytisine ( 17 ), N -(3-oxobutyl)cytisine ( 18 ), (−)-rhombifoline ( 19 ), methyl ester of 3-( N -cytisinyl)propanoic acid ( 20 ), thermseedline P ( 21 ), methyl ester of N -cytisinylacetic acid ( 22 ), thermseedline P ( 23 ), cytisine ( 24 ), N -methylcytisine ( 25 ), N -formylcytisine ( 26 ), N -acylcytisine ( 27 ), (−)-12-hydroxycytisine ( 28 ), cytisine-12-carbamide ( 29 ), thermseedline K ( 30 ), thermopsine ( 31 ) (Figure ), 13β-hydroxylthermopsine ( 32 ), thermseedline O ( 33 ), anagyrine ( 34 ), epibaptifoline ( 35 ), baptifoline ( 36 ), 13β-acetoxyanagyrine ( 37 ), (−)-lupanine ( 38 ), (+)-5,6-dehydrolupanine ( 39 ), daidzein ( 40 ), isoformononetin ( 41 ), 3 ′ ,4 ′ ,7-trihydroxyisoflavone ( 42 ), 4 ′ ,7-dihydroxy-3 ′ -methoxyisoflavone ( 43 ), cabreuvin ( 44 ), orobol ( 45 ), genistein ( 46 ), formononetin ( 47 ), 4 ′ ,7-dimethoxy-5-hydroxyisoflavone ( 48 ), 3 ′ -hydroxyglycitein ( 49 ), glycitein ( 50 ), 7-hydroxy-3-(4-hydroxy-phenyl)-5-methoxy-chromen-4-one ( 51 ), erythrinin B ( 52 ), and ononin ( 53 ) …”

Section: Resultsmentioning

confidence: 99%

Quinolizidine Alkaloids and Isoflavones from the Herb of Thermopsis lupinoides and Their Antiviral, Antifungal, and Insecticidal Activities

Zhang,

Tian,

Zhang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

As part of our ongoing investigation of natural bioactive substances from the genus Thermopsis of the tribe Fabaceae for agricultural protection, the chemical constituents of the herb Thermopsis lupinoides were systematically investigated, which led to the isolation of 39 quinolizidine alkaloids (QAs) (1−39), including 14 new QAs (1−14) and 14 isoflavones (40−53). Their structures were elucidated through comprehensive spectroscopic data analysis (IR, UV, NMR, HRESIMS), ECD calculations, and Xray crystallography. The antitomato spotted wilt virus (TSWV) and antifungal (against Botrytis cinerea, Gibberella zeae, Phytophythora capsica, and Alternaria alternata) and insecticidal (against Aphis fabae and Tetranychus urticae) activities of the isolated compounds were screened using the lesion counting method, mycelial inhibition assay, and spray method, respectively. The bioassay results showed that 34 exhibited excellent protective activity against TSWV, with an EC 50 value of 36.04 μg/mL, which was better than that of the positive control, ningnanmycin (86.03 μg/mL). The preliminary mechanistic exploration illustrated that 34 induced systemic acquired resistance in the host plant by acting on the salicylic acid signaling pathway. Moreover, 1 showed significant antifungal activity against B. cinerea (EC 50 value of 20.83 μg/mL), while 2 exhibited good insecticidal activity against A. fabae (LC 50 value of 24.97 μg/mL). This research is promising for the invention of novel pesticides from QAs with high efficiency and satisfactory ecological compatibility.

show abstract

Section: Resultsmentioning

confidence: 99%

Quinolizidine Alkaloids and Isoflavones from the Herb of Thermopsis lupinoides and Their Antiviral, Antifungal, and Insecticidal Activities

Zhang,

Tian,

Zhang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…X-ray crystallography of another related alkaloid, anagyrine [2], isolated from the leaves of Thermopsis turcica, confirmed its structure.The aqueous extract of the leafy shoots of Sophora griffithii Stocks (Leguminosae), a plant cultivated throughout the warm regions of northern Asia, is occasionally used as a crude drug in folk medicine for its stomachic, diuretic, antipyretic, and analgesic properties and as an insecticide (1,2). Previously a number of quinolizidine alkaloids and flavanoids have been isolated from this plant (3)(4)(5). The present study describes the isolation and structure determination of a new type of tetracyclic quinolizidine alkaloid, named sophazrine [1], from the leafy shoots.…”

mentioning

confidence: 99%