Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Cinelli, Maris A.; Jones, A. Daniel

doi:10.3390/molecules26092629

Cited by 31 publications

(28 citation statements)

References 150 publications

(413 reference statements)

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“…The largest total alkaloid of Parkia timoriana seeds as much as 48.90 mg/g was found in the methanol extract. Alkaloids are low molecular weight compounds and are generally alkaline due to the presence of a nitrogen atom in their heterocyclic ring (Nobahar et al 2021), so alkaloids range from polar to semi-polar compounds (Cinelli and Jones 2021). Methanol is a compound that has a molecular structure of CH 3 OH, is polar because it has a hydroxyl group (-OH), and is non-polar because it has a methyl group (-CH 3 ) (Ramdani et al 2017).…”

Section: Discussionmentioning

confidence: 99%

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Metabolite Bioactive Contents of Parkia timoriana (DC) Merr Seed Extracts in Different Solvent Polarities

et al. 2022

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Parkia roxburghii G.Don seeds have popular folkloric ethnomedicinal use in the treatment of many diseases especially in Indonesia. Methanol, distilled water, n-hexane, and ethyl acetate extracts from the seeds of Parkia roxburghii were assayed for secondary metabolism quantitative, antioxidant, antidiabetic and antibacterial and activities as well as determined the presence of phytochemical constituents. The extracts were investigated for antioxidant possession by DPPH free-radical (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2’ Azinobis (3-ethylbenz-thiazoline-6-sulfonic-acid) scavenging ability, Antidiabetic potential was invitro assayed by α-amylase inhibition and α-glucosyde inhibition while antibacterially by applying the disk diffusion procedure, as well as refined for the attendance of bioavailable phytochemical components. The result showed the existence of phytochemical components in diverse extracts could attribution free scavenging, antidiabetic and antimicrobial activities. The qualitative results all extracts of Parkia roxburghii seeds have expressed the presence of alkaloid, flavonoid, steroid, terpenoids, saponins and tannin whereas, methanol, distilled water, and n-hexane extracts expressed the presence of anthraquinones, The entire phenolic contents were examined as attested by the Follin-Ciocalteu methods, which varied from 43.82 - 137.42 mg GAE/g. The entire flavonoid compounds were measured with aluminum chloride colorimetric procedure, which varied from 20.42 – 45.90 mg QEDW/g. The total phenolic compound were measure Follin Ciocalteu which varied from 43.82-137.42 mg/g. The alkaloid, saponin, tanic acid, terpenoid and cardiac glycoside quantitative were measured with spectrofotometri UV-VIS which varied from 16.34 – 48.90 mg for alkaloid. The Saponin content varied 1.76 – 16.04 mg/g. Tanic acid which varied 0.21 – 7.29 mg/g. Terpenoid which varied 50.12 – 91.02 mg/g. Cardiac glycoside which varied 7.24-36.53 mg/g. The potential antioxidant were measured with ABTS and DPPH method, the methanol extract is the potential antioxidant. Antidiabetic potential were measured with alfa amylase and alfa glucosyde inhibition, the best antidiabetic is methanol extract. The potential antibacterial and antifungal was the methanol extract for Eschericia Coli and Candida Albicans. The conclusion established the tremendous perspective of the Parkia roxburghii seeds as another option fountain of food supplement, as well as drug components.

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Section: Discussionmentioning

confidence: 99%

“…Alkaloids are plant-friendly chemicals that act as a deterrent to predators and parasites. Alkaloids have been noted to possess antimicrobial, antihypertensive, antifungal, anti-inflammatory, anti-fibrogenic effects as well as anti-diarrheal effects which may be related to their action on the small intestine (Cinelli and Jones 2021).…”

Section: Discussionmentioning

confidence: 99%

Metabolite Bioactive Contents of Parkia timoriana (DC) Merr Seed Extracts in Different Solvent Polarities

et al. 2022

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“…After the seeds are used for oil extraction, sunflower receptacles have largely been discarded [ 4 , 5 , 6 ], which not only wastes resources, but also pollutes the environment. Sunflower receptacles contains many active compounds, including flavonoids [ 7 , 8 ], alkaloids [ 9 , 10 ], and chlorogenic acid [ 11 , 12 ]. However, there are few existing studies on the essential oil of sunflower receptacles.…”

Section: Introductionmentioning

confidence: 99%

Clustering Analysis, Structure Fingerprint Analysis, and Quantum Chemical Calculations of Compounds from Essential Oils of Sunflower (Helianthus annuus L.) Receptacles

Liu

Han

et al. 2022

IJMS

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Sunflower (Helianthus annuus L.) is an appropriate crop for current new patterns of green agriculture, so it is important to change sunflower receptacles from waste to useful resource. However, there is limited knowledge on the functions of compounds from the essential oils of sunflower receptacles. In this study, a new method was created for chemical space network analysis and classification of small samples, and applied to 104 compounds. Here, t-SNE (t-Distributed Stochastic Neighbor Embedding) dimensions were used to reduce coordinates as node locations and edge connections of chemical space networks, respectively, and molecules were grouped according to whether the edges were connected and the proximity of the node coordinates. Through detailed analysis of the structural characteristics and fingerprints of each classified group, our classification method attained good accuracy. Targets were then identified using reverse docking methods, and the active centers of the same types of compounds were determined by quantum chemical calculation. The results indicated that these compounds can be divided into nine groups, according to their mean within-group similarity (MWGS) values. The three families with the most members, i.e., the d-limonene group (18), α-pinene group (10), and γ-maaliene group (nine members) determined the protein targets, using PharmMapper. Structure fingerprint analysis was employed to predict the binding mode of the ligands of four families of the protein targets. Thence, quantum chemical calculations were applied to the active group of the representative compounds of the four families. This study provides further scientific information to support the use of sunflower receptacles.

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“…Atropine is used to treat diseases related to the pupil, hay fever, colds, intestinal spasms, and as an antidote to toxic gases and insecticides. However, the disadvantages of this drug in higher doses far outweigh the bene ts and signi cantly expand the anticholinergic effect and psychiatric patients [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Fe 3 O 4 and bimetal–organic framework Zn/Mg composites peroxides- like catalyze luminol chemiluminescence for specific measurement of atropine in Datura plant

Mahmoudi

Chaichi

Shamsipur³

et al. 2022

Preprint

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Atropine(AT) is a tropane alkaloid used as an anticholinergic drug. This substance is abundantly found in Datura plant seeds. In this work, Zn/Mg bimetallic MOF was integrated with Fe3O4, and Fe3O4@Zn/Mg MOF(Fe3O4@MOF) composite was synthesized. This compound has a high peroxidase-like activity based on the chemiluminescence (CL) reaction. The synergistic effect of Zn, Fe, and Mg metals in the Fenton reaction causes the production of reactive oxygen species(ROS), resulting in high CL intensity. Addition of AT quenching CL and thus AT can be measured. The linear range and limit of detection(LOD) of this method for measuring AT standard solution are 3-600µgL− 1 and 10 − 4µgL− 1, respectively. This method is easy, fast, reversible, selective, without biodegradability effects, low cost, high accuracy, and precision for measuring AT in the Datura plant.

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Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

Cited by 31 publications

References 150 publications

Metabolite Bioactive Contents of Parkia timoriana (DC) Merr Seed Extracts in Different Solvent Polarities

Metabolite Bioactive Contents of Parkia timoriana (DC) Merr Seed Extracts in Different Solvent Polarities

Clustering Analysis, Structure Fingerprint Analysis, and Quantum Chemical Calculations of Compounds from Essential Oils of Sunflower (Helianthus annuus L.) Receptacles

Fe 3 O 4 and bimetal–organic framework Zn/Mg composites peroxides- like catalyze luminol chemiluminescence for specific measurement of atropine in Datura plant

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