Alkaloids of Terpenoid Origin (excepting indole alkaloids and ergot alkaloids)

Seigler, David S.

doi:10.1007/978-1-4615-4913-0_36

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The subsequent formation of ring E is the result of the attack of the C-20 amine on the C-18 methyl following oxidation of the group (Figure 3). 34,35…”

Section: Introductionmentioning

confidence: 99%

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

Karim

Ismail

Osman

2022

Natural Product Communications

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Steroidal alkaloids are derived from the steroid skeleton with one or two nitrogen atoms. They are widely distributed in tropical and subtropical regions and possess a range of biological activities. The structures of steroidal alkaloids are comparable to those of anabolic steroids, steroidal hormones, and corticosteroids, making them a valuable source for drug discovery. Taxonomically, steroidal alkaloids are limited in distribution to certain plant families, predominantly the Apocynaceae, Buxaceae, Solanaceae, and Liliaceae. This review highlights the steroidal alkaloids from the Apocynaceae family and their biological activities. The articles published from 1919 to 2021 were included in this review. A total of 163 steroidal alkaloids and 12 biological activities were reported from plant species belonging to the Apocynaceae family in this period. Of the 410 genera in the Apocynaceae, only 10 contain steroidal alkaloids. Although some alkaloids from the Apocynaceae family were also reported in the Buxaceae family, especially tetracyclic triterpenes with a pregnane side chain, most steroidal alkaloids can only be found in several genera of the Apocynaceae family.

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“…The subsequent formation of ring E is the result of the attack of the C-20 amine on the C-18 methyl following oxidation of the group (Figure 3). 34,35…”

Section: Introductionmentioning

confidence: 99%

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

Karim

Ismail

Osman

2022

Natural Product Communications

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Dimeric Sesquiterpenoids

Liao¹,

Yue²

2016

Progress in the Chemistry of Organic Natural Products 101

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It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents. As dimeric molecules might be able to act on both moieties of a dimeric protein, dimeric sesquiterpenoids (DSs), which are generated biogenetically from coupling of two sesquiterpenoid molecules, are in essence potential biologically active molecules, and have attracted in recent years great attention for their peculiar structures and biological activities. In fact, a number of DSs are more potent than their monomeric precursors for some activities such as anti-inflammatory, anti-tumor, immunosuppressive, potassium channel blocking, antimalarial, anti-virus, and neurotrophic activities.The complex and diversified structures of DSs also attracted attention of chemists in their isolation, structural elucidation, and synthetic construction.In the contribution, a general view of the classification and distribution of DSs will be provided. Strategies for the structural elucidation of DSs and their analogues is presented. Chemical strategies for the convergence of the two sesquiterpenoid units is reviewed. Biological activities are discussed under each type of activity.

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Alkaloids of Terpenoid Origin (excepting indole alkaloids and ergot alkaloids)

Cited by 2 publications

References 20 publications

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

Dimeric Sesquiterpenoids

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