Alkaloids of Peganum harmala. Unusual reaction of peganine and vasicinone

Telezhenetskaya, M. V.; D'yakonov, A. L.

doi:10.1007/bf00636573

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…In general, the molecular mechanisms involved in growth inhibition by plant extracts are: the inhibition of DNA gyrase, responsible for DNA biosynthesis, energy production metabolism and cellular respiration; inactivation of essential enzymes and the function of genetic material; and interference with membrane permeability, modification of the fungal cell structure. (Telezhemetskaya and D'yakonov, 1991;Cushnie and Lamb, 2005;Xu et al, 2011;Wu et al, 2013;Silva et al, 2014;Yang et al, 2016;Pangallo et al, 2017). In addition, plant extracts can stimulate the host's defensive responses, initiate oxidative stress and react with the pathogen's cell membrane proteins (Yang et al, 2016;Papoutsis et al, 2019).…”

Section: Natural Product and Plant Extract Applicationsmentioning

confidence: 99%

Penicillium italicum: An Underexplored Postharvest Pathogen

et al. 2020

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In the agricultural sector, citrus is one of the most important fruit genus in the world. In this scenario, Brazil is the largest producer of oranges; 34% of the global production, and exporter of concentrated orange juice; 76% of the juice consumed in the planet, summing up US$ 6.5 billion to Brazilian GDP. However, the orange production has been considerable decreasing due to unfavorable weather conditions in recent years and the increasing number of pathogen infections. One of the main citrus post-harvest phytopathogen is Penicillium italicum, responsible for the blue mold disease, which is currently controlled by pesticides, such as Imazalil, Pyrimethanil, Fludioxonil, and Tiabendazole, which are toxic chemicals harmful to the environment and also to human health. In addition, P. italicum has developed considerable resistance to these chemicals as a result of widespread applications. To address this growing problem, the search for new control methods of citrus post-harvest phytopathogens is being extensively explored, resulting in promising new approaches such as biocontrol methods as “killer” yeasts, application of essential oils, and antimicrobial volatile substances. The alternative methodologies to control P. italicum are reviewed here, as well as the fungal virulence factors and infection strategies. Therefore, this review will focus on a general overview of recent research carried out regarding the phytopathological interaction of P. italicum and its citrus host.

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Section: Natural Product and Plant Extract Applicationsmentioning

confidence: 99%

Penicillium italicum: An Underexplored Postharvest Pathogen

et al. 2020

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“…The activity of the harmal crude extracts may be related to the content of alkaloids such as harmine, harmaline, and tetrahydroharmine besides phenolic compounds that can alter the permeability of fungal cells [76]. The exact mechanism of action of phenols has not yet been determined; however, it is already known that they can inactivate essential enzymes and disrupt function of the genetic material [100].…”

Section: Alternative Control Methodsmentioning

confidence: 99%

Biological Control of Citrus Postharvest Phytopathogens

Bazioli

Belinato

Costa

et al. 2019

Toxins

108

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Citrus are vulnerable to the postharvest decay caused by Penicillium digitatum, Penicillium italicum, and Geotrichum citri-aurantii, which are responsible for the green mold, blue mold, and sour rot post-harvest disease, respectively. The widespread economic losses in citriculture caused by these phytopathogens are minimized with the use of synthetic fungicides such as imazalil, thiabendazole, pyrimethanil, and fludioxonil, which are mainly employed as control agents and may have harmful effects on human health and environment. To date, numerous non-chemical postharvest treatments have been investigated for the control of these pathogens. Several studies demonstrated that biological control using microbial antagonists and natural products can be effective in controlling postharvest diseases in citrus, as well as the most used commercial fungicides. Therefore, microbial agents represent a considerably safer and low toxicity alternative to synthetic fungicides. In the present review, these biological control strategies as alternative to the chemical fungicides are summarized here and new challenges regarding the development of shelf-stable formulated biocontrol products are also discussed.

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“…Taking into account the fact that plant extracts consist of a mixture of different compounds, it is easier to speculate that the antifungal activity should be the outcome of a plethora of possible modes of actions. In general, those modes of action are linked with: i) the stimulation of defence responses (Pangallo et al, 2017), ii) the inhibition of nucleic acid biosynthesis via the inhibition of DNA gyrase (Wu, Zang, He, Pan, & Xu, 2013), iii) the ability to interfere with the cytoplasmic plasma membrane of the pathogen, inducing alternation in fluidity and outflow of intercellular substances (Cushnie & Lamb, 2005), iv) the modification of pathogen cell structure (Xu, Zhou, & Wu, 2011), v) the arrest of cellular respiration and initiation of oxidative stress syndromes (Yang et al, 2016), vi) the inhibition of energy production metabolism (Yang et al, 2016), and vii) the inactivation of enzymes, causing disruption of the functionality of the genetic material (Telezhenetskaya & D'yakonov, 1991).…”

Section: Use Of Plant Extractsmentioning

confidence: 99%

“…membrane proteinsTelezhenetskaya and D'yakonov (1991) Disrupt function of genetic materialTelezhenetskaya and D'yakonov (1991) Required Characteristics Effective after short term treatment applicationTalibi et al (2014) No negative effect upon fruit quality attributes Talibi et al (2014) Low effective dose Tripathi and Dubey (2004) Efficiency not affected by environmental conditions or fruit physiology Li Destri Nicosia et al (2016) Low residual activitynot toxic to humans Li Destri Nicosia et al (2016) Specificity of action versus targeted pathogens Li Destri Nicosia et al (2016)…”

mentioning

confidence: 99%