Alkaloids of<i>Fumaria densiflora</i>*

Popova, M. E.; Šimánek, Vilı́m; Novak, Johannes; Dolejš, L.; Sedmera, Petr; Preininger, V.

doi:10.1055/s-2007-969932

Cited by 9 publications

(2 citation statements)

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“…It is one of the 40 species of the genus Fumaria (Fumariaceae), which have been employed for centuries in folk medicine and some of which are components of phytotherapeutic preparations exerting choleretic and spasmolytic effects 1,2 . The following isoquinoline alkaloids have been identified in F. densiflora: fumaramine 3,4 , adlumidiceine, densiflorine, coptisine, cryptopine, palmatine, protopine, sinactine 5 , adlumidine, bicuculline fumadensine, fumaridine, fumariline, fumaritine, hydrastine, isosalutaridine, N-methylhydrasteine, parfumidine, parfumine, and scoulerine 6 . In the context of a phytochemical investigation of the genus Fumaria we reexamined F. densiflora of Bulgarian origin.…”

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Fumaria densiflora DC. Alkaloids

Táborská

Bochořáková

Soušek

et al. 1996

Collect. Czech. Chem. Commun.

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Twenty isoquinoline alkaloids were identified in the aerial part of Fumaria densiflora DC. In addition to bicuculline, densiflorine, fumaritine, fumariline, scoulerine, coptisine, cryptopine, parfumine, protopine, and sinactine which have been found previously, the following alkaloids were isolated for the first time from this species: adlumine, fumaricine, fumaritridine, fumarophycine, fumarofine, corytuberine, cis-N-methylstylopinium iodide, stylopine, and two new 1-benzylisoquinoline alkaloids, viz. fumaflorine and fumaflorine methyl ester. The cytoprotectivity of extracts of F. densiflora and F. officinalis, and that of protopine, cryptopine, and parfumine was tested on primary cultures of rat hepatocytes intoxicated with carbon tetrachloride. The cytoprotective effect of the extracts is associated with the alkaloids.

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“…The plant was collected at the same site as in 1983 (ref. 5 ). The current paper deals with the isolation and characterization of alkaloids, with the cytoprotective activity of Fumaria extracts and of three major alkaloids of this plant, using a model of rat hepatocytes.…”

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confidence: 99%