Alkaloids of Genista acanthoclada DC.: Genista acanthoclada DC.'nın Alkaloitleri

Abstract

In this research, six quinolizidine alkaloids were isolated from the aerial parts of Genista acanthoclada and their picrates were prepared. They were identified as sparteine, retamine, lupanine, anagyrine, N-methylcytisine and cytisine by TLC, melting points, IR spectra and elementary analysis. The total alkaloid content of aerial parts of Genista acanthoclada was found to be 0.12 % by using titrimetric method (1). ÖZET Bu çalışmada Genista acanthoclada'nın toprak üstü kısımlarından altı kinolizidin alkaloidi izole edilmiş ve pikrat tuzları hazırlanmıştır. Bu bileşikler, İTK, ergime dereceleri, IR spektrumları ve elementel analizleri ile spartein, retamin, anagirin, N-metilsitisin ve sitisin ola rak teşhis edilmiştir. Titrimetrik yöntemle yapılan miktar tayininde Genista acanthoclada'nın toprak üstü kısımlarının total alkaloit miktarı % 0.12 olarak bulunmuştur.

Indolizidine and quinolizidine alkaloids

“…Key steps in a short synthesis of racemic monomorine I (Scheme 1 2)56 include ethanolysis of the a-nitrocyclohexanone (77), reductive cyclization of the product to a 2,5-cisdisubstituted pyrrolidine, and further cyclization by way of the a-iodoester (78). This cyclization produced a mixture of two indolizidines ; the undesired epimer (79) could be isomerized to (80) by iodination a to the ester followed by reduction of the iminium salt produced therefrom. The overall yield for this short sequence was 29% based on (77).…”