Alkaloids from Mongolian speciesHypecoum lactiflorumKar. et Kir. Pazij

Abstract

A new secoberbine alkaloid (-)-N-methylcorydalisol was isolated from the aerial parts of Hypecoum lactiflorum Kar. et Kir. Pazij. (Papaveraceae) of Mongolian origin and was characterised. The known alkaloids of protopine and protoberberine type protopine, allocryptopine, (-)-N-methylcanadine and (-)-N-methylstylopine were also isolated. (-)-N-methylstylopine is a new alkaloid for the genus, while (-)-N-methylcanadine is new for the species. All structures were established by physical and spectral analysis.

Hypecoum spp.—Chemistry and Biological Activity of Alkaloids

“…This section summarizes the alkaloid compounds that have been identified in the Hypecoum spp. since 1972 (Table 2) [2,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]27,[40][41][42][43][44][45][46][47][48][49][50]. So far, a total of 86 naturally occurring alkaloids have been reported for ten plant species-H. procumbens, H. procumbens var.…”

“…procumbens H. procumbens var. glaucescens H. leptocarpum [8,11,40] (S)-Bulbocapnine (31) H. imberbe [9] (S)-Glaucine (32) H. procumbens [8] H. procumbens [8] (S)-Magnoflorine ( 33) (S)-Corydalisol (39) H. procumbens [8] (S)-N-Methylcorydalisol (40) H. lactiflorum [7] (S)-Dihydroleptopine (…”

“…H. leptocarpum [22,23,43] Hypecocarpinine (42) H. leptocarpum [24] Hypecocarpine (43) H. leptocarpum [27] Leptopinine (44) H. leptocarpum [12] H. lactiflorum [7] (S)-Dihydroleptopine (41) (Coryximine)…”

“…The known alkaloids in the genus belong to the various classes of isoquinolines-protopines, protoberberines, benzophenanthridines, aporphines, simple isoquinolines, secoberbines, spirobenzylisoquinolines and others. Protopine is a predominant alkaloid isolated from all investigated plants of the genus [2,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Besides being biologically active compounds, isoquinoline alkaloids are characteristic secondary metabolites in the family Papaveraceae and can be used for chemotaxonomic purposes [25].…”

Application of chromatography technology in the separation of active alkaloids from Hypecoum leptocarpum and their inhibitory effect on fatty acid synthase

“…The plant is widely used in traditional Tibetan medicine as an antipyretic, analgesic, and anti‐inflammatory substance , with specific employment found in the treatment of colds, hepatitis, pneumonia, cholecystitis, and food poisoning . Research performed using modern analytical chemistry and natural product extraction techniques have revealed a number of pharmacologically active alkaloids in H. leptocarpum , with the majority of compounds being tetrahydroisoquinoline alkaloids such as protopine , cryptopine , allocryptopine , oxohydrastinine , leptocarpinine , leptopine , etc.…”