Alkaloids from Houttuynia cordata Thunb. and their chemotaxonomic significance

Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

“…This alkaloid was first isolated from the mealworm T. molitor, 16 and later from the leaves of P. erosus 17 and P. sarmentosum, 18 and the whole plants of H. cordata Thunb. 19 Compound 5 had identical 1 H and 13 C NMR data (DMSO-d 6 ) to those of the alkaloid from the mealworm (Table 2) as well as the published NMR data of the alkaloid from plants. 17,19 However, the ESI-HRMS data of compound 5 showed the m/z at 268.1039 [M + H] + , calculated at 268.1040, corresponding to the molecular formula C 10 H 13 O 4 N 5 , which did not match with the structure of the alkaloid from the mealworm.…”

“…sarmentosum, and the whole plants of H. cordata Thunb . Compound 5 had identical 1 H and 13 C NMR data (DMSO- d 6 ) to those of the alkaloid from the mealworm (Table ) as well as the published NMR data of the alkaloid from plants. , However, the ESI-HRMS data of compound 5 showed the m / z at 268.1039 [M + H] + , calculated at 268.1040, corresponding to the molecular formula C 10 H 13 O 4 N 5 , which did not match with the structure of the alkaloid from the mealworm.…”

“…For example, a recent article proposed that compound 5 (misassigned structure) could be used as a chemotaxonomic marker to distinguish H. cordata from other plants. 19 This has become a serious issue if using the misassigned structure of a natural product as a chemotaxonomic marker. Upon the example given above, the misassigned natural product, compound 5, should be revised to adenosine (6) as soon as possible.…”

“…In this paper, we describe the isolation and structure elucidation of new geranylresorcinol derivatives and propose a structure revision of an alkaloid, 3-[2,3-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol, previously isolated from the mealworm Tenebrio molitor, 16 and later from the leaves of Pachyrhizus erosus 17 and Piper sarmentosum, 18 and the whole plants of Houttuynia cordata Thunb. 19 Biological screening revealed potential drug candidates for breast cancer treatments. This information will be useful for the future development of anticancer drugs based on edible mushrooms.…”

“…erinaceus showed the most promising results, but there is little information available for breast cancer therapies using this mushroom. In this paper, we describe the isolation and structure elucidation of new geranyl-resorcinol derivatives and propose a structure revision of an alkaloid, 3-[2,3-dihydroxy-4-(hydroxymethyl)­tetrahydrofuran-1-yl]-pyridine-4,5-diol, previously isolated from the mealworm Tenebrio molitor, and later from the leaves of Pachyrhizus erosus and Piper sarmentosum, and the whole plants of Houttuynia cordata Thunb . Biological screening revealed potential drug candidates for breast cancer treatments.…”