Alkaloids from Fungi

Silva, Jani; Garcia, Juliana; Guimarães, Rafaela; Palito, Cátia; Lemos, André; Barros, Lillian; Alves, Maria José

doi:10.1007/978-3-031-18587-8_16

Cited by 2 publications

(2 citation statements)

References 105 publications

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“…Alkaloid molecules contain an N atom and have great structural diversity. Depending on the function of the amine, alkaloids can act as either a hydrogen-receptor or a hydrogen-donor for hydrogen bonding, which is crucial for the drug to exert its function [37]. It is worth mentioning that we have isolated multiple different types of alkaloids from A. fumigatus, including indole diketopiperazine alkaloids, quinazoline alkaloids, and pyridine alkaloids.…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Sang,

Zhang,

Qiu

et al. 2024

Molecules

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A new bergamotane sesquiterpenoid, named xylariterpenoid H (1), along with fourteen known compounds (2–15), were isolated from the crude extract of Aspergillus fumigatus, an endophytic fungus isolated from Delphinium grandiflorum L. Their structures were elucidated mainly by extensive analyses of NMR and MS spectroscopic data. In addition, the screening results of antibacterial and cytotoxic activities of compounds 1–15 showed that compound 4 displayed antibacterial activities against Staphylococcus aureus and MRSA (methicillin-resistant S. aureus) with an MIC value of 3.12 µg/mL.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Sang,

Zhang,

Qiu

et al. 2024

Molecules

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“…As a result, the production of such mixed (or hybrid) fungal BGCs results in chimeric secondary metabolites such as NRPS/PKS, NRPS/terpenoid, PKS/terpenoid, or alkaloid/terpenoid hybrids ( Figure 1 e–h) [ 67 , 160 , 207 ]. Some (but not all) alkaloids also use core enzymes for their construction [ 208 , 209 ]; for example, ergot alkaloids use NRPS [ 210 , 211 ]. In rare cases, secondary metabolites in fungi result from crosstalk between two separate BGCs [ 212 ].…”

Section: Biosynthetic Gene Clusters (Bgcs) For the Production Of Fung...mentioning

confidence: 99%

Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle

Zhgun

2023

IJMS

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Filamentous fungi are one of the most important producers of secondary metabolites. Some of them can havse a toxic effect on the human body, leading to diseases. On the other hand, they are widely used as pharmaceutically significant drugs, such as antibiotics, statins, and immunosuppressants. A single fungus species in response to various signals can produce 100 or more secondary metabolites. Such signaling is possible due to the coordinated regulation of several dozen biosynthetic gene clusters (BGCs), which are mosaically localized in different regions of fungal chromosomes. Their regulation includes several levels, from pathway-specific regulators, whose genes are localized inside BGCs, to global regulators of the cell (taking into account changes in pH, carbon consumption, etc.) and global regulators of secondary metabolism (affecting epigenetic changes driven by velvet family proteins, LaeA, etc.). In addition, various low-molecular-weight substances can have a mediating effect on such regulatory processes. This review is devoted to a critical analysis of the available data on the “turning on” and “off” of the biosynthesis of secondary metabolites in response to signals in filamentous fungi. To describe the ongoing processes, the model of “piano regulation” is proposed, whereby pressing a certain key (signal) leads to the extraction of a certain sound from the “musical instrument of the fungus cell”, which is expressed in the production of a specific secondary metabolite.

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Alkaloids from Fungi

Cited by 2 publications

References 105 publications

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus

Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle

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