Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans

Abstract

Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called 'Annona senegalensis' and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (1), (-)-anonaine (2), (-)-asimilobine (3) and (+)-nornantenine (4). This is the first report on the isolation of compounds 1, 3 and 4 from this plant. Compounds 2 and 4 showed good activity, whereas 1 and 3 displayed weak inhibition against Streptococcus mutans (ATCC 25175). The results showed that compound 2 and 3 showed significant activity with a minimum inhibition concentration (MIC) of 0.12 and 0.25 mg/mL, respectively. The present study reports for the first time the antibacterial activity of the extract of A. senegalensis and its constituents. As S. mutans is a rather resistant bacteria, the MIC obtained during the present study is significant.

Screening of antidiabetic and antioxidant potential along with phytochemicals of Annona genus: a review

“…The study identified acetogenin and annosenegalin from the seed extract of Annona senegalansis and annogalene; gigantetronenine; squamocine; glaucanisine; glaucanetine; goniothalamicine from the root extract. Six alkaloids were also found out, namely roemerine; anonaine; nornuciferine; liriodenine; coclaurine; isoboldine, from the leave extract of Annona senegalensis [42][43][44][45][46].…”

Antibacterial and antibiofilm activities of Prangos acaulis Bornm. extract against Streptococcus mutans: an in silico and in vitro study

“…In a similar research lee et al revealed that S. mutans biofilm had the highest level of sensitivity for the extract of Sophora flavescens (45). Furthermore, several studies aimed at investigating the anti-bacterial and anti-biofilm activities of pure phytochemicals and some compounds such as linoleic, linolenic, oleanolic, betulinic acids, betulin, beta-sitosterol glucoside and carvacrol introduced as effective compounds against dental caries development and S. mutans biofilm formation (16,46,47). Due to costly and time consuming of convention methods for evaluation, drug likeness and anti-bacterial activities of phytochemicals currently in silico methods have been regarded.…”

Metabolomic profile of medicinal plants with anti-RVFV activity

“… Plant names Family Antiviral activities References Sutherlandia frutescens Fabaceae HIV1 RT, IN, RNase H Bessong et al., (2005) , 2006 ; Harnett et al., (2005) Prunus africana Rosaceae CMV Tolo et al., (2007) Carissa edulis Apocynaceae HSV-1 CDV, CPIV, FHV, LSDV PV-2 CMV Mukhtar et al. (2008) ; Tolo et al., (2006) Bagley (2018) Al-youssef and Hassan (2014) Tolo et al., (2007) Elaeodendron transvaalense Celastraceae HIV-1, RT, CB, IN Tshikalange et al., (2008) ; Bessong et al., (2005) , 2006 Terminalia sericea Combretaceae HIV1 RT HIV-1 RNA-dependent-DNA polymerase (RDDP) Tshikalange et al., (2008) Bessong et al., (2005) Crinum macowanii Amaryllidaceae HIV-1 RT, PR Klos et al., (2009) Ziziphus mucronata Rhamnaceae HIV-1 RT, RNase H Bessong et al., (2005) Helichrysum aureonitens Asteraceae HSV-1, reovirus Meyer et al., (1997) Euclea natalensis Ebenaceae HSV-1 Lall et al., (2017) Senna petersiana Fabaceae HIV1-RT Tshikalange et al., (2008) Adansonia digitata Malvaceae HSV-1 NDV HSV-1; ASFV HIV1 RT, HIV-FRET, PR Rathore et al., (2007) S...…”