2022
DOI: 10.1155/2022/6257778
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Alkaloids from Aconitum carmichaelii Alleviates DSS-Induced Ulcerative Colitis in Mice via MAPK/NF-κB/STAT3 Signaling Inhibition

Abstract: Fuzi (Aconitum carmichaelii Debx) has been traditionally used for the treatment of ulcerative colitis (UC) in China for thousands of years. The total alkaloids of A. carmichaelii (AAC) have been considered as the main medicinal components of fuzi, whereas its underlying anti-UC mechanisms remain elusive. In the present study, the dextran sulfate sodium (DSS)-induced UC mice model, which was consistent with the symptoms and pathological features of human UC, was established to comprehensively evaluate the anti-… Show more

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Cited by 6 publications
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“…Proinflammatory cytokines can activate an IKK complex which phosphorylates IκB proteins and then actives NF-κB proteins ( Perkins, 2006 ). Next, they will be further activated by post-translational modifications (phosphorylation, acetylation, glycosylation) and translocate to the nucleus where it upregulates the expressions of TNF-α, IL-6, and IL-1β, which further activates the NF-κB signaling pathway and causes inflammatory cascade reaction ( Huang et al, 2022 ). This study displayed that BF distinctly reduced both the expression and phosphorylation of NF-κB p65 ( Figures 6E,F ).…”
Section: Discussionmentioning
confidence: 99%
“…Proinflammatory cytokines can activate an IKK complex which phosphorylates IκB proteins and then actives NF-κB proteins ( Perkins, 2006 ). Next, they will be further activated by post-translational modifications (phosphorylation, acetylation, glycosylation) and translocate to the nucleus where it upregulates the expressions of TNF-α, IL-6, and IL-1β, which further activates the NF-κB signaling pathway and causes inflammatory cascade reaction ( Huang et al, 2022 ). This study displayed that BF distinctly reduced both the expression and phosphorylation of NF-κB p65 ( Figures 6E,F ).…”
Section: Discussionmentioning
confidence: 99%