Alkaloids and other compounds from seeds of Tabernaemontana cymosa

A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd.

“…Chromatography of the latter fraction over silica gel yielded 10. [6], alangilignoside C (6) [8,9], dehydrodiconiferyl glucoside E (7) [10], ursolic acid (8) [11], oleanolic acid (9) [12], and lupeol (10) [13] ( Fig. 1), respectively, based on their spectral and physical data.…”

New Cardenolide and Acylated Lignan Glycosides from the Aerial Parts of Asclepias curassavica

“…C-NMR spectroscopic data, the aglycone of 23 was expected to be a tetrahydrofuran-type lignan. The deacylated compound 23a afforded by alkaline hydrolysis of 23 was identified as (8R,7ЈS,8ЈR)-5,5Ј-dimethoxylariciresinol 9Ј-O-b-D-glucopyranoside, the 1 H-, 13 C-NMR spectroscopic data and circular dichroism (CD) spectrum being consistent with those of alangilignoside C. 24,25) Moreover, the sults suggested that the C-6 position of the b-D-glucopyranosyl group was acylated by trans-ferulic acid. Hence, the structure of 23 was elucidated as shown in Chart 1.…”

Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells

“…Tabernaemontana plants are characterized to produce various skeletal types of indole alkaloids, including iboga-type, aspidosperma-type, vobasinyl-ibogan-type and tetrakis-aspidosperma-type (Vanbeek et al, 1984(Vanbeek et al, , 1985. These alkaloids have shown a wide range of biological activities including cytotoxicity, reversal of vincristine-resistance, antimicrobial activity against Gram-positive bacteria, antifungal activity, and acetylcholinestrase inhibitory activity (Vanbeek, et al, 1985;Achenbach et al, 1997;Kam et al, 1998;Chaturvedula et al, 2003;Andrade et al, 2005).…”