Alkaloid-rich extract of Lannea egregia leaf protect against cardiomyopathy in streptozotocin-induced type 2 diabetic rats

Ajiboye, B.O.; Folorunso, I.M.; Akinfemiwa, K.I.; Oyinloye, B.E.; Lawal, O.E.; Ojo, O.A.; Ezema, M.; Ajuwon, O.R.; Ardekani, E.A.

doi:10.1016/j.phyplu.2023.100513

Cited by 1 publication

(1 citation statement)

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“…This feat has been corroborated by the previous study. , Antioxidant enzymes are pivotal in maintaining redox balance and safeguarding the normal kidneys against oxidative stress. SOD combats superoxide radicals by converting them into hydrogen peroxide, while CAT and GPx neutralize hydrogen peroxide, preventing the accumulation of reactive oxygen species (ROS). , This collective defense mechanism preserves the kidney’s structural and functional integrity. In pathological states, such as kidney diseases, an imbalance between ROS production and antioxidant defenses leads to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats

Ajiboye,

Famusiwa,

Nifemi

et al. 2024

ACS Omega

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Diabetes-induced kidney damage represents a substantial health hazard, emphasizing the imperative to explore potential therapeutic interventions. This study investigates the nephroprotective activity of flavonoid-rich extracts from Hibiscus sabdariffa leaves in streptozotocin-induced diabetic rats. The flavonoid-rich extracts of H. sabdariffa leaves was obtained using a standard procedure. The animals were induced with streptozotocin and thereafter treated with both low (LDHSFL) and high doses (HDHSFL) of flavonoid-rich extracts from H. sabdariffa leaves and metformin (MET), and other groups are diabetic control (DC) and normal control (NC). The study assesses diverse renal parameters, encompassing kidney redox stress biomarkers, serum electrolyte levels, kidney inflammatory biomarkers, serum concentrations of creatinine, urea, and uric acid, kidney phosphatase activities, renal histopathology, and relative gene expressions of kidney injury molecule-1 (KIM-1) and transforming growth factor beta-1 (TGF-1β), comparing these measurements with normal and diabetic control groups (NC and DC). The findings indicate that the use of extracts from H. sabdariffa leaves markedly (p < 0.05) enhanced renal well-being by mitigating nephropathy, as demonstrated through the adjustment of various biochemical and gene expression biomarkers, indicating a pronounced antioxidative and anti-inflammatory effect, improved kidney morphology, and mitigation of renal dysfunction. These findings suggest that H. sabdariffa leaf flavonoid extracts exhibit nephroprotective properties, presenting a potential natural therapeutic approach for the treatment of diabetic nephropathy.

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